[BioC] unbalanced factorial design

[Christian Landry]

Hi,

I am analyzing microarray data from a factorial design, with treatments and 
genotypes. I would like to know if some of you have experience with 
Bioconductors packages doing Mixed-Model Anova that deal with unbalanced 
design, i.e. not the same number of replicates for each treatment-genotype 
combination. I am particularly interested in the interaction between 
treatment and genotype so I know that the design is an issue. Any references?

Thanks in advance,

Christian