[BioC] GCRMA/RMA bimodal distribution
zwu at jhsph.edu
Tue Aug 31 20:07:01 CEST 2004
> Sorry for including the developers, but I guess you are the only ones
> that will be able to answer this, (and I'm not sure BioC accepts .docs).
> I saw a comment from Jean addressing the same question but couldn't find
> the reply he referred to.
The original questioin I got was about the bimodal distribution of gcrma
result from probe intensities with unimodel distribution. My answer was
that the "change" was not necessarily surprising.
For example , when you have "true log signal" from a bimodal distribution
# You will see this has two peaks
#if the background, log(non-specific binding) come from
#then when you plot the histogram of convolution in log scale,
#you see only one peak, and this would be "before gcrma".
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