[BioC] RMA and GeneCluster

Huang, Mingqian MHUANG1 at partners.org
Wed Oct 15 18:10:18 MEST 2003


I'm trying to use GeneCluster to analyze our GeneChip data normalized with RMA.
However, there is another normalization option in GeneCluster:

Normalize to Mean ____ and Variance ____

The results I got with or without this step are quite different, even though the
data has been treated with RMA. What does this normalization process do? Should
I do this step + RMA or should I just rely on RMA?

Thanks for your help.

Mingqian Huang

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