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<p class="MsoNormal">Dear all,<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">PSI (Statisticians in the Pharmaceutical Industry) is holding the one-day event ‘Time-to-event and Recurrent Event Endpoints in Clinical Trials’ at the Novartis Campus in Basel on Tuesday, October 29, 2019.
<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Cox proportional hazard models and Kaplan-Meier curves often constitute the standard statistical analysis of clinical trials when the primary interest is in a single event such as progression-free survival, death, etc. However, there are
event-driven trials in which the mentioned methods cannot capture the complexity of the primary event of interest. Examples include: (i) trials in which the occurrence of the primary event of interest is precluded by a different event, e.g. death precludes
events such as hospitalizations; (ii) trials in which the primary event of interest is a recurrent event, i.e. an event that can occur multiple times for a single patient such as exacerbations in asthma.
<o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<p class="MsoNormal">This PSI one-day event provides the opportunity to hear from knowledgeable speakers from health authorities, academia, and pharma. The speakers will share their thoughts, ideas and experiences, including case studies, on a range of particular
issues relating to planning, conduct, and analysis of event-driven trials. A variety of non-standard time-to-event and recurrent event models for clinical trials will be presented and their implications for the estimand framework will be discussed.
<o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<p class="MsoNormal">Please find more information about the event, speakers, and presentation here:
<a href="https://www.psiweb.org/events/event-item/2019/10/29/default-calendar/psi-one-day-meeting-time-to-event-and-recurrent-event-endpoints-in-clinical-trials">
https://www.psiweb.org/events/event-item/2019/10/29/default-calendar/psi-one-day-meeting-time-to-event-and-recurrent-event-endpoints-in-clinical-trials</a>. Please also note that this site includes the registration information.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Please do not hesitate to contact us if you have any questions.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Thank you and kind regards,<o:p></o:p></p>
<p class="MsoNormal">David and Tobias on behalf of the PSI Scientific Committee <o:p>
</o:p></p>
<p class="MsoNormal"><a href="mailto:David.lawrence@novartis.com">David.lawrence@novartis.com</a>
<o:p></o:p></p>
<p class="MsoNormal"><a href="mailto:Tobias.muetze@novartis.com">Tobias.muetze@novartis.com</a>
<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
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