[Statlist] Next talk: Friday, 14.09.2018, with Vanessa Didelez, Leibniz-Institut für Präventionsforschung und Epidemiologie - BIPS

[Maurer Letizia]

E-mail from the  Statlist using stat.ch<mailto:Statlist using stat.ch>  mailing list
_______________________________________________
ETH and University of Zurich

Organisers:

Proff. P. Bühlmann - L. Held - T. Hothorn - M. Maathuis -
N. Meinshausen - S. van de Geer - M. Wolf

****************************************************************************

We are glad to announce the following talk:

Friday, 14.09.2018, at 15.15 h  ETH Zurich HG G19.1
with Vanessa Didelez, Leibniz-Institut für Präventionsforschung und Epidemiologie - BIPS

********************************************************************************************************


Title:

Assumptions for Mendelian Randomisation Studies with Multiple Instruments<https://www.math.ethz.ch/sfs/news-and-events/research-seminar.html?s=hs18#e_12356>

Abstract:

Mendelian randomisation (MR) refers to situations where a genetic predisposition can be exploited as an instrumental variable (IV) to estimate the causal effect of a modifiable risk factor or exposure on an outcome of interest. For example, the ALDH2 gene is associated with alcohol consumption, and has therefore successfully been used as an IV to estimate the causal effect of alcohol on outcomes related to coronary heart disease. MR analyses have become very popular especially recently with the increased availa-bility of GWAS data. This gives rise to a number of challenges, especially around the theme of multiple IVs as it is common that several SNPs are found to be associated with an exposure of interest. However, the validity of such multiple IVs can often not been established in a convincing way and numerous methods that claim to allow for multiple but partially invalid IVs have been put forward in the last few years. In this talk I will propose and investigate a formal notion of „valid IV“ in the context of multiple and potentially invalid IVs - this has been neglected by all of the previous literature but turns out to be crucial to assess the plausbility of the various available methods.


This abstract is also to be found under the following link: http://stat.ethz.ch/events/research_seminar

*******************************************************************************************************************

Statlist mailing list
Statlist using stat.ch<mailto:Statlist using stat.ch>
https://stat.ethz.ch/mailman/listinfo/statlist

	[[alternative HTML version deleted]]