Dear R users,

I am working with the medical imaging data, and got the following set to
analyse.:

N=13 patients with one tumor. Three slices S1,S2,S3 from three independent
tumor regions (upper, mid, bottom) are CT scanned which results in the
CT-specific measures CT for each tumor:  CT1, CT2, CT3. Concurrently,
corresponding histology outcomes for these slices (H: H1, H2, H3) are
provided.


We want to find whether there is dependence between CT and histology
outcomes for the patients in sample. Tumor slice is grouping factor and
three regression lines (one for each slice) are developed; the tumor
heterogeneity makes a difference between the lines.


I want to know whether in R nlme:  lme(H ~ CT, random=~CT|Slice) applies
here, or should look for the crossed-random effect (??) since we take
random patients and sort of random (upper, mid, and bottom) slices of the
tumors.



Thanks a lot in advance, robert

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