Hello.
I am a M.S student in statistics and I did my thesis with MLE(I learn it from Mixed Effect Models in S-Splus book (D.M.Bates). and I want to use NLME becouse of improving  my results, but in Mixed Effect Models in S-Splus book (D.M.Bates) there is examples just for 1 covariate datas and used some espicial models such as  biexponential model. but my data have 5covariates with 1 response variable, (Y~X1+X2+X3+X4|grouped) ,would you please help me what kind of models I can use with how many parameters.
 best regard


      
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