[R-sig-ME] Advice for modelling a crossover RCT

[Jorge Teixeira]

Dear everyone,

I am going to conduct a randomized crossover study where participants
(about 20) are divided into 2 groups due to logistics constraints. The
study involves participants performing 4 different exercise modalities
(i.e., 4 conditions) in a randomized order, in two SEQUENCEs. So, there are
a total of 8 sessions (2 for each exercise modality), per participant.



Given this setup, I am unsure about what is the correct mixed-effects model
to use in this case, and also any further insights or considerations you
believe I should need... I'll be more than happy to listen!



Some suggestions:

M1 -> Y ~ GROUP + CONDITION + (1 | ID)

M2 -> Y ~ GROUP + CONDITION + SEQUENCE + PERIOD +  (1 | ID / SEQUENCE /
PERIOD)

 M3 -> Y ~ GROUP + CONDITION + (1 | ID / SEQUENCE / PERIOD)



Thank you in advance for the help

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