[R-sig-ME] Precision about the glmer model for Bernoulli variables
D. Rizopoulos
d@r|zopou|o@ @end|ng |rom er@@mu@mc@n|
Wed Apr 29 08:41:39 CEST 2020
Mixed models can assume negative correlations when you include something more than random intercepts. Check
https://emcbiostatistics.shinyapps.io/Repeated_Measurements/
Chapter 3, Section 3.3 -> Select random intercepts & random slopes, and make the correlation between the intercepts and slopes negative. When including quadratic random slopes even get more negative correlations.
Best,
Dimitris
��
Dimitris Rizopoulos
Professor of Biostatistics
Erasmus University Medical Center
The Netherlands
________________________________
From: R-sig-mixed-models <r-sig-mixed-models-bounces using r-project.org> on behalf of David Duffy <David.Duffy using qimrberghofer.edu.au>
Sent: Wednesday, April 29, 2020 8:23:03 AM
To: Vaida, Florin <fvaida using health.ucsd.edu>; John Maindonald <john.maindonald using anu.edu.au>
Cc: r-sig-mixed-models using r-project.org <r-sig-mixed-models using r-project.org>
Subject: Re: [R-sig-ME] Precision about the glmer model for Bernoulli variables
Hi Florin.
> ...but negative correlations do not correspond to a mixed-effects model specification. (I thought Geert
> Molenberghs had a paper to this point but I can't find it now.)
Hopefully still vaguely R-related - in the case of meta-analyses of correlations, the observed correlation for a given, say, sub-study can be negative, and _some_ mixed models will inappropriately truncate this contribution at zero, leading to inflated estimates for the global parameters. This comes up when meta-analysing heritability, where the genetic model (as you have pointed out) contrains this to be non-negative for a single trait.
Because of the computational difficulties, many geneticists still fit linear-normal mixed models to binary data (eg genome-wide association studies of large datasets eg UK Biobank), and don't usually get burnt. The "better" alternative for this has been PQL, implemented in several R packages.
Cheers, David Duffy.
_______________________________________________
R-sig-mixed-models using r-project.org mailing list
https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fstat.ethz.ch%2Fmailman%2Flistinfo%2Fr-sig-mixed-models&data=02%7C01%7Cd.rizopoulos%40erasmusmc.nl%7C5b7ae5701bf24a34e2a608d7ec05d2be%7C526638ba6af34b0fa532a1a511f4ac80%7C0%7C1%7C637237382072594631&sdata=O%2FiLczmjWal5AWB7GVxb0MFuotrQynWbWqOACIbNSgI%3D&reserved=0
[[alternative HTML version deleted]]
More information about the R-sig-mixed-models
mailing list