[R-sig-ME] c++ exception (unknown reason) when using an offset of the slope with glmer

Ben Bolker bbolker at gmail.com
Tue Jan 27 14:14:05 CET 2015

  Your posted data set got removed by the mailing list machinery.  Can
you post it somewhere publicly accessible?

On Tue, Jan 27, 2015 at 3:45 AM,  <xavier.paoletti at curie.fr> wrote:
> Dear all,
> I am new on this forum and I hope my request follows the right format.
> I use R 3.1.2 and lme1.7 on a mac OS X (snow leopard) or Windows OS.
> I try to fit a longitudinal logistic mixed effect model on dose-time
> response data where the response is measured several times at the same
> dose. The probability of response increases with the dose.
> There is a set of discrete doses (let's say 6) but most of the data are
> measured at 1 or 2 doses.
> I use a very simple logstic model with a random intercept and the dose
> effect.
> In the simplest case, there is not time effect.
> Furthermore, I would like to set the slope of the dose to some value using
> offset slope=1.5.
> The command line,
> glmer(DLTb ~ offset(slope*dose) + (1 | patid),
> family=binomial,data=dataAllCRM,nAGQ=10)
> gives the following error:
> Under Mac OSX: (function (fr, X, reTrms, family, nAGQ = 1L, verbose = 0L,
> control = glmerControl(),  :
>   c++ exception (unknown reason)
> Under Windows: Error: (maxstephalfit) PIRLS step-halvings failed to reduce
> deviance in pwrssUpdate
> Whatever the value of the offset, I get the same error.
> If I remove the offset or if I remove the variable, some estimates are
> obtained.
> Please find attached an example of dataset as an illustration; I get the
> same error for all tested datasets.
> Thank you very much for your help.
> Best regards,
> Xavier
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