[R-sig-ME] Multivariate mixed effects model

[Afshartous, David]

All,

Has anyone performed a multivariate mixed model with lme or lmer?  An
example of such a model is in Fieuws & Verbeke (2004), "Joint modelling of
multivariate longitudinal profiles, pitfalls of the random effects
approach," Statistics in Medicine, 23:3093-3104.  They also developed a
pairwise fitting method for the case when the number of response variable is
large (Biometrics 2006; 62:424-431), and the implementation was done in SAS.
In any event, I'd rather avoid SAS and do my analysis in R and was wondering
if anyone here could provide any pointers.  Not much turned up in the
archives on this.

Cheers,
David


David Afshartous, Ph.D.
University of Miami
Miller School of Medicine
Division of Clinical Pharmacology
1500 N.W. 12th Avenue, 15th Floor West
Miami, Florida 33136