[R-sig-ME] nonlinear mixed longitudinal model

dave fournier otter at otter-rsch.com
Tue Apr 28 18:36:20 CEST 2009

If you want freely available software to do this you could look at
AD Model Builder's Random Effects Module available at


It combines the different advantages of software available on R and SAS
in that it deals with arbitrary nonlinear models like SAS, but also
allows crossed effects and in principal any level of nesting and
can use sparse matrix algorithms on the Hessian. It will do
the Laplace approximation for you.

David A. Fournier
P.O. Box 2040,
Sidney, B.C. V8l 3S3
Phone/FAX 250-655-3364

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