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Dear Reza,</div>
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Thanks for your response. I want to see the correlation between them pain and BDNF. </div>
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##For pain</div>
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pain <- escalc(measure = "SMD", n1i = nexp, m1i = Int_mean, sd1i = Int_sd, n2i = ncon, m2i = Con_mean, sd2i = Con_sd, data = dat_pain)</div>
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<span style="background-color: rgb(255, 255, 255);">##For</span><span style="font-size: 12pt;">BDNF</span></div>
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bdnf <- escalc(measure = "MD", n1i = nexp, m1i = Intmean, sd1i = Intsd, n2i = ncon, m2i = Conmean, sd2i = Consd, data = dat_bdnf)</div>
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<span style="background-color: rgb(255, 255, 255);">Please find my dataset below.</span></div>
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<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
study_label</div>
</td>
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<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
nexp</div>
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<td style="width: 38.2396px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
ncon</div>
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<td style="width: 80.375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap;"><br>
</div>
</td>
<td style="width: 60.5938px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
Int_mean</div>
</td>
<td style="width: 44.3854px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
Int_sd</div>
</td>
<td style="width: 66.3125px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
Con_mean</div>
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<td style="width: 50.0417px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
Con_sd</div>
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<td style="width: 45.7917px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
BDNF</div>
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<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
Intmean</div>
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<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
Intsd</div>
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<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
Conmean</div>
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<td style="width: 44.25px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
Consd</div>
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<td style="width: 207.292px; white-space: nowrap; vertical-align: middle; height: 23.3333px; box-sizing: border-box;">
<div style="text-align: left; white-space: nowrap; font-family: Aptos, sans-serif; font-size: 12pt; color: black;">
Ali et al., 2022 </div>
</td>
<td align="right" style="width: 37.9375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
32</div>
</td>
<td align="right" style="width: 38.2396px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
16</div>
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<td style="width: 80.375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
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PCP-intensity</div>
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<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-7.32</div>
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<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
4.26</div>
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<td align="right" style="width: 66.3125px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-3.87</div>
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<td align="right" style="width: 50.0417px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
6.12</div>
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<td style="width: 45.7917px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
ng/ml</div>
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<td align="right" style="width: 54.7604px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
0.89</div>
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<td align="right" style="width: 41.6042px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
18.98</div>
</td>
<td align="right" style="width: 60.4167px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
0.94</div>
</td>
<td align="right" style="width: 44.25px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
19.19</div>
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<div style="text-align: left; white-space: nowrap; font-family: Aptos, sans-serif; font-size: 12pt; color: black;">
Mustafaoglu et al., 2024 </div>
</td>
<td align="right" style="width: 37.9375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
34</div>
</td>
<td align="right" style="width: 38.2396px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
17</div>
</td>
<td style="width: 80.375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
NPS(0-10)</div>
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<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-3.91</div>
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<td align="right" style="width: 44.3854px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
1.489</div>
</td>
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<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-1.91</div>
</td>
<td align="right" style="width: 50.0417px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
1.56</div>
</td>
<td style="width: 45.7917px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
ng/ml</div>
</td>
<td align="right" style="width: 54.7604px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-15.76</div>
</td>
<td align="right" style="width: 41.6042px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
32.42</div>
</td>
<td align="right" style="width: 60.4167px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-10.99</div>
</td>
<td align="right" style="width: 44.25px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
27.43</div>
</td>
</tr>
<tr>
<td style="width: 207.292px; white-space: nowrap; vertical-align: middle; height: 23.3333px; box-sizing: border-box;">
<div style="text-align: left; white-space: nowrap; font-family: Aptos, sans-serif; font-size: 12pt; color: black;" class="elementToProof">
Rustem et al., 2024 </div>
</td>
<td align="right" style="width: 37.9375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
34</div>
</td>
<td align="right" style="width: 38.2396px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
17</div>
</td>
<td style="width: 80.375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
NPS(0-10)</div>
</td>
<td align="right" style="width: 60.5938px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-3.12</div>
</td>
<td align="right" style="width: 44.3854px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
1.42</div>
</td>
<td align="right" style="width: 66.3125px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-2.19</div>
</td>
<td align="right" style="width: 50.0417px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
1.51</div>
</td>
<td style="width: 45.7917px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
ng/ml</div>
</td>
<td align="right" style="width: 54.7604px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-15.27</div>
</td>
<td align="right" style="width: 41.6042px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
35.77</div>
</td>
<td align="right" style="width: 60.4167px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-3.77</div>
</td>
<td align="right" style="width: 44.25px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
31.46</div>
</td>
</tr>
<tr>
<td style="width: 207.292px; white-space: nowrap; vertical-align: middle; height: 23.3333px; box-sizing: border-box;">
<div style="text-align: left; white-space: nowrap; font-family: Aptos, sans-serif; font-size: 12pt; color: black;">
Dall’Agnol et al., 2014 </div>
</td>
<td align="right" style="width: 37.9375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
12</div>
</td>
<td align="right" style="width: 38.2396px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
12</div>
</td>
<td style="width: 80.375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
VAS(0-10)</div>
</td>
<td align="right" style="width: 60.5938px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-3.37</div>
</td>
<td align="right" style="width: 44.3854px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
2.45</div>
</td>
<td align="right" style="width: 66.3125px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-1.54</div>
</td>
<td align="right" style="width: 50.0417px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
2.63</div>
</td>
<td style="width: 45.7917px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
ng/ml</div>
</td>
<td align="right" style="width: 54.7604px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
38.07</div>
</td>
<td align="right" style="width: 41.6042px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
21.39</div>
</td>
<td align="right" style="width: 60.4167px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
25.68</div>
</td>
<td align="right" style="width: 44.25px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
10.69</div>
</td>
</tr>
<tr>
<td style="width: 207.292px; white-space: nowrap; vertical-align: middle; height: 23.3333px; box-sizing: border-box;">
<div style="text-align: left; white-space: nowrap; font-family: Aptos, sans-serif; font-size: 12pt; color: black;">
de Paula et al., 2023</div>
</td>
<td align="right" style="width: 37.9375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
21</div>
</td>
<td align="right" style="width: 38.2396px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
22</div>
</td>
<td style="width: 80.375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
VAS(0-10)</div>
</td>
<td align="right" style="width: 60.5938px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-0.42</div>
</td>
<td align="right" style="width: 44.3854px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
2.66</div>
</td>
<td align="right" style="width: 66.3125px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-1.45</div>
</td>
<td align="right" style="width: 50.0417px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
2.45</div>
</td>
<td style="width: 45.7917px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
ng/ml</div>
</td>
<td align="right" style="width: 54.7604px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-1.56</div>
</td>
<td align="right" style="width: 41.6042px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
5.17</div>
</td>
<td align="right" style="width: 60.4167px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-1.23</div>
</td>
<td align="right" style="width: 44.25px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
3.97</div>
</td>
</tr>
<tr>
<td style="width: 207.292px; white-space: nowrap; vertical-align: middle; height: 23.3333px; box-sizing: border-box;">
<div style="text-align: left; white-space: nowrap; font-family: Aptos, sans-serif; font-size: 12pt; color: black;">
Lao et al., 2023 </div>
</td>
<td align="right" style="width: 37.9375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
22</div>
</td>
<td align="right" style="width: 38.2396px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
21</div>
</td>
<td style="width: 80.375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
VAS(0-10)</div>
</td>
<td align="right" style="width: 60.5938px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-1.09</div>
</td>
<td align="right" style="width: 44.3854px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
2.44</div>
</td>
<td align="right" style="width: 66.3125px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-0.2</div>
</td>
<td align="right" style="width: 50.0417px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
2.44</div>
</td>
<td style="width: 45.7917px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
ng/ml</div>
</td>
<td align="right" style="width: 54.7604px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-1.32</div>
</td>
<td align="right" style="width: 41.6042px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
6.22</div>
</td>
<td align="right" style="width: 60.4167px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-0.52</div>
</td>
<td align="right" style="width: 44.25px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
5.56</div>
</td>
</tr>
<tr>
<td style="width: 207.292px; white-space: nowrap; vertical-align: middle; height: 23.3333px; box-sizing: border-box;">
<div style="text-align: left; white-space: nowrap; font-family: Aptos, sans-serif; font-size: 12pt; color: black;">
Graca-Tarragó et al., 2019 </div>
</td>
<td align="right" style="width: 37.9375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
15</div>
</td>
<td align="right" style="width: 38.2396px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
15</div>
</td>
<td style="width: 80.375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
VAS(0-10)</div>
</td>
<td align="right" style="width: 60.5938px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-3.69</div>
</td>
<td align="right" style="width: 44.3854px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
2.41</div>
</td>
<td align="right" style="width: 66.3125px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-3.15</div>
</td>
<td align="right" style="width: 50.0417px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
2.14</div>
</td>
<td style="width: 45.7917px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
ng/ml</div>
</td>
<td align="right" style="width: 54.7604px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-6.94</div>
</td>
<td align="right" style="width: 41.6042px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
36.6</div>
</td>
<td align="right" style="width: 60.4167px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-1.42</div>
</td>
<td align="right" style="width: 44.25px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
32.29</div>
</td>
</tr>
<tr>
<td style="width: 207.292px; white-space: nowrap; vertical-align: middle; height: 23.3333px; box-sizing: border-box;">
<div style="text-align: left; white-space: nowrap; font-family: Aptos, sans-serif; font-size: 12pt; color: black;">
Fatif et al., 2019 </div>
</td>
<td align="right" style="width: 37.9375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
15</div>
</td>
<td align="right" style="width: 38.2396px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
15</div>
</td>
<td style="width: 80.375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
VAS(0-10)</div>
</td>
<td align="right" style="width: 60.5938px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-6.41</div>
</td>
<td align="right" style="width: 44.3854px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
1.73</div>
</td>
<td align="right" style="width: 66.3125px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-4.22</div>
</td>
<td align="right" style="width: 50.0417px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
2.31</div>
</td>
<td style="width: 45.7917px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
ng/ml</div>
</td>
<td align="right" style="width: 54.7604px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-15.2</div>
</td>
<td align="right" style="width: 41.6042px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
32.39</div>
</td>
<td align="right" style="width: 60.4167px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
0.49</div>
</td>
<td align="right" style="width: 44.25px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
31.27</div>
</td>
</tr>
<tr>
<td style="width: 207.292px; white-space: nowrap; vertical-align: middle; height: 23.3333px; box-sizing: border-box;">
<div style="text-align: left; white-space: nowrap; font-family: Aptos, sans-serif; font-size: 12pt; color: black;">
Medeiros et al., 2016</div>
</td>
<td align="right" style="width: 37.9375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
11</div>
</td>
<td align="right" style="width: 38.2396px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
12</div>
</td>
<td style="width: 80.375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
VAS(0-10)</div>
</td>
<td align="right" style="width: 60.5938px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-4.04</div>
</td>
<td align="right" style="width: 44.3854px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
2.18</div>
</td>
<td align="right" style="width: 66.3125px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-4.26</div>
</td>
<td align="right" style="width: 50.0417px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
2.52</div>
</td>
<td style="width: 45.7917px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
ng/ml</div>
</td>
<td align="right" style="width: 54.7604px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
3.23</div>
</td>
<td align="right" style="width: 41.6042px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
16.75</div>
</td>
<td align="right" style="width: 60.4167px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
2.23</div>
</td>
<td align="right" style="width: 44.25px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
13.1</div>
</td>
</tr>
<tr>
<td style="width: 207.292px; white-space: nowrap; vertical-align: middle; height: 23.3333px; box-sizing: border-box;">
<div style="text-align: left; white-space: nowrap; font-family: Aptos, sans-serif; font-size: 12pt; color: black;" class="elementToProof">
Ahmed et al., 2016 </div>
</td>
<td align="right" style="width: 37.9375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
12</div>
</td>
<td align="right" style="width: 38.2396px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
11</div>
</td>
<td style="width: 80.375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
VAS(0-10)</div>
</td>
<td align="right" style="width: 60.5938px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-5.29</div>
</td>
<td align="right" style="width: 44.3854px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
2.19</div>
</td>
<td align="right" style="width: 66.3125px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-2.67</div>
</td>
<td align="right" style="width: 50.0417px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
<span style="background-color: rgb(255, 255, 255);">2.11</span></div>
</td>
<td style="width: 45.7917px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
<span style="background-color: rgb(255, 255, 255);">ng/ml</span></div>
</td>
<td align="right" style="width: 54.7604px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
3.18</div>
</td>
<td align="right" style="width: 41.6042px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
30.43</div>
</td>
<td align="right" style="width: 60.4167px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;" class="elementToProof">
-7.27</div>
</td>
<td align="right" style="width: 44.25px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
37.32</div>
</td>
</tr>
<tr>
<td style="width: 207.292px; white-space: nowrap; vertical-align: middle; height: 23.3333px; box-sizing: border-box;">
<div style="text-align: left; white-space: nowrap; font-family: Aptos, sans-serif; font-size: 12pt; color: black;" class="elementToProof">
Zhao et al., 2019</div>
</td>
<td align="right" style="width: 37.9375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
24</div>
</td>
<td align="right" style="width: 38.2396px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
24</div>
</td>
<td style="width: 80.375px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div class="elementToProof" style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
NRS(0-10)</div>
</td>
<td align="right" style="width: 60.5938px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;" class="elementToProof">
-0.25</div>
</td>
<td align="right" style="width: 44.3854px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div class="elementToProof" style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
0.72</div>
</td>
<td align="right" style="width: 66.3125px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div class="elementToProof" style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
0.08</div>
</td>
<td align="right" style="width: 50.0417px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
<span style="background-color: rgb(255, 255, 255);">1.04</span></div>
</td>
<td data-editing-info="{"bgColorOverride":true}" style="width: 45.7917px; height: 23.3333px; white-space: nowrap; background-color: rgb(255, 255, 255); vertical-align: bottom; color: rgb(0, 0, 0); box-sizing: border-box;">
<div class="elementToProof" style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
<span style="background-color: rgb(255, 255, 255);">ng/mL</span></div>
</td>
<td align="right" style="width: 54.7604px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
14.58</div>
</td>
<td align="right" style="width: 41.6042px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;" class="elementToProof">
25.96</div>
</td>
<td align="right" style="width: 60.4167px; white-space: nowrap; vertical-align: bottom; box-sizing: border-box; height: 23.3333px;">
<div class="elementToProof" style="white-space: nowrap; font-family: Calibri, sans-serif; font-size: 11pt; color: black;">
-7.86</div>
</td>
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26.06</div>
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<span style="color: black;">Best regards,</span></p>
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<span style="color: black;"><br>
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<span style="font-family: Verdana, sans-serif; font-size: 9pt; color: black;"><b>Ishtiaq Ahmed</b></span></p>
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<span style="font-family: Verdana, sans-serif; font-size: 9pt; color: black;"><b> </b></span></p>
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<span style="font-family: Verdana, sans-serif; font-size: 8pt; color: black;"><b>Ph.D. Researcher</b></span></p>
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<span style="font-size: 8pt;">Faculty of Physical Education and Physiotherapy</span></p>
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<span style="font-size: 8pt;">Department KIMA/KINE</span></p>
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<span style="font-family: Verdana, sans-serif; font-size: 8pt; color: black; background-color: rgb(255, 255, 255);">Vrije Universiteit Brussels</span></p>
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<span style="font-family: Verdana, sans-serif; font-size: 8pt; color: black;">Pleinlaan 2 - 1050 Brussel -
<a href="https://www.vub.be/" id="OWAabea6c94-8947-e7bf-3d03-ed9124292e53" class="OWAAutoLink" style="margin: 0px;">
www.vub.be</a></span></p>
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<span style="background-color: rgb(255, 255, 255);">Pain in Motion International Research Group –
</span><span style="color: rgb(12, 100, 192); background-color: rgb(255, 255, 255);"><a href="http://www.paininmotion.be/" target="_blank" id="OWAe4d1c097-bc1b-547d-68b5-b650eca25062" class="OWAAutoLink" rel="noopener noreferrer" data-linkindex="17" data-safelink="true" data-auth="NotApplicable" style="color: rgb(12, 100, 192); margin: 0px; background-color: rgb(255, 255, 255);">www.paininmotion.be</a></span></div>
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<div id="divRplyFwdMsg" dir="ltr"><font face="Calibri, sans-serif" style="font-size:11pt" color="#000000"><b>From:</b> Reza Norouzian <rnorouzian@gmail.com><br>
<b>Sent:</b> Saturday, 20 April 2024 16:20<br>
<b>To:</b> R Special Interest Group for Meta-Analysis <r-sig-meta-analysis@r-project.org><br>
<b>Cc:</b> Ishtiaq Ahmed <Ishtiaq.Ahmed@vub.be><br>
<b>Subject:</b> Re: [R-meta] Correlation between two continuous outcome</font>
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<div dir="ltr">Hi Ishtiaque,
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<div>Can you possibly share a little more specifics about the dataset you are working with? For example, how many studies do you have? How many of them simultaneously studied the effect of X intervention on both pain intensity and the several pain biomarkers
of interest? Indeed, how many pain biomarkers do you have and are there any that is/are not the focus of your study?</div>
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<div>Also, if you could share the structure of your data for a couple of studies in a concise manner (ex. below), our list members could likely better assist you.</div>
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<div>Reza</div>
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<div>study SMD V intensity PDNF . . . last_pain_biomarkers <br>
1 .6 .1 number number number<br>
1 1 .2 number number number<br>
1 .9 .3 number number number<br>
2 .7 .2 number number number<br>
2 .8 .4 number number number<br>
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<div class="x_gmail_quote">
<div dir="ltr" class="x_gmail_attr">On Fri, Apr 19, 2024 at 10:30 AM Ishtiaq Ahmed via R-sig-meta-analysis <<a href="mailto:r-sig-meta-analysis@r-project.org">r-sig-meta-analysis@r-project.org</a>> wrote:<br>
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<blockquote class="x_gmail_quote" style="margin:0px 0px 0px 0.8ex; border-left:1px solid rgb(204,204,204); padding-left:1ex">
Hi everyone,<br>
I hope everyone is doing well. My understanding of correlation meta-analysis is limited, and I'm seeking to enhance it. Currently, I'm conducting a meta-analysis to assess the effect of X intervention on both pain intensity and several pain biomarkers (such
as BDNF, beta-endorphin, etc.) as compared with the control. I'm particularly interested in exploring the correlation between pain intensity and BDNF levels, both of which are continuous variables.<br>
I used escalc() to calculate the standardized mean difference (SMD) for pain intensity, considering the varying measurement scales between the intervention and control groups. Additionally, I've also calculated the mean difference (MD) for BDNF levels using
the differences between the intervention and control groups.<br>
My question is whether it's possible to convert SMD/MD to correlation coefficient (r) to perform the correlation meta-analysis. Alternatively, are there other approaches to utilizing SMD and MD for this analysis? Additionally, some of the studies (though not
all) have provided beta-values for the correlation between pain intensity and BDNF. Can I incorporate these beta-values into the meta-analysis?<br>
<br>
I would greatly appreciate any suggestions or sources you can provide.<br>
<br>
<br>
<br>
Best regards,<br>
<br>
<br>
Ishtiaq Ahmed<br>
<br>
<br>
<br>
Ph.D. Researcher<br>
<br>
Vrije Universiteit Brussels<br>
<br>
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