<div dir="ltr"><div><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"><span class="gmail-Apple-tab-span" style="white-space:pre"></span></span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Hi.</span></div><div><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"><br></span></div><div><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Let me know if you need me to provide the data for this example. Screenshots in the bottom.</span></div><div><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"><br></span></div><div><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">I ran this MA with REML, and the weight for random and common effects are exactly the same! Never saw anything like this.  </span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">t</span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">2</span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"> values also don’t look plausible. </span></div><div><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"><br></span></div><div>
<div><b><u>#1</u></b></div><div>vo2 <- metacont(en  , em, esd, cn, cm, csd, study, method.tau = "REML", prediction = TRUE, data = dat_vo2, sm = "MD")<br>vo2</div>

</div><div><br></div><div><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Is this a bug or a particular issue of low number of studies and low sample size?</span></div><div><br></div><div><b><u>#2</u></b></div><div>vo2 <- metacont(en  , em, esd, cn, cm, csd, study, method.tau = "DL", prediction = TRUE, data = dat_vo2, sm = "MD")<br>vo2</div><div><br></div><div>
<div><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"><span class="gmail-Apple-tab-span" style="white-space:pre"></span></span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">I ran this with DL estimator and weights and </span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">t</span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">2</span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"> are plausible. I also ran other similar MA using REML and this was all okay.</span> <br></div>

</div><div><br></div><div>#1 using SMD instead of MD also looks fine.</div><div><br></div><div><br></div><div>Thanks,</div><div>Jorge<br></div><div><br></div><div><br></div><div><b><u>REML:</u></b></div><div><br></div><div><img src="cid:ii_lfi7nfw41" alt="image.png" width="491" height="186"><br><br></div><div><br></div><div><b><u>DL:</u></b></div><div><img src="cid:ii_lfi7n1zg0" alt="image.png" width="491" height="194"><br><br></div></div>