<html>
<head>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
</head>
<body text="#000000" bgcolor="#FFFFFF">
<p>Dear Awais,</p>
<p>Survival data using the hazard ratio as effect measure are
typically meta-analysed using the inverse variance method. The
following general R packages for meta-analysis provide this
method: <b>epiR</b>, <b>meta</b>, <b>metafor</b>, <b>rmeta</b>
(see <a class="moz-txt-link-freetext" href="https://cran.r-project.org/web/views/MetaAnalysis.html">https://cran.r-project.org/web/views/MetaAnalysis.html</a>).<br>
</p>
<p>The inverse variance method needs, for each study, the <u>log</u>
hazard ratio and its standard error as input. You write that you
have hazard ratios and CIs which is sufficient as standard errors
can be calculated from CIs (see Parmar et al., 1999).</p>
<p>Please find attached R code using R package <b>meta</b> which
conducts a meta-analysis for survival data from a Cochrane review
I was involved. Note, the minor differences in the results of the
two meta-analyses can be explained by rounding hazard ratios and
confidence limits to only two significant digits; we would get
identical results with more significant digits.<br>
</p>
<p>Best wishes, Guido</p>
<p>Reference: Parmar MK, Torri V, Stewart L. Extracting summary
statistics to perform meta-analyses of the published literature
for survival endpoints. Statistics in Medicine.
1998;17(24):2815–34. <span class="Z3988"
title="url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fzotero.org%3A2&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Extracting%20summary%20statistics%20to%20perform%20meta-analyses%20of%20the%20published%20literature%20for%20survival%20endpoints&rft.jtitle=Statistics%20in%20Medicine&rft.volume=17&rft.issue=24&rft.aufirst=M.%20K.&rft.aulast=Parmar&rft.au=M.%20K.%20Parmar&rft.au=V.%20Torri&rft.au=L.%20Stewart&rft.date=1998&rft.pages=2815-34&rft.spage=2815&rft.epage=34&rft.issn=0277-6715"></span></p>
<blockquote type="cite"
cite="mid:CAHdcJs5t_Mds3Fc+-FY9Sx2+wYAigT-80QWgjTVvY=3NmiaHBw@mail.gmail.com"></blockquote>
<pre class="moz-signature" cols="72">--
Dr. Guido Schwarzer
Institute of Medical Biometry and Statistics,
Faculty of Medicine and Medical Center - University of Freiburg
Postal address: Stefan-Meier-Str. 26, D-79104 Freiburg
Phone: +49/761/203-6668
Mail: <a class="moz-txt-link-abbreviated" href="mailto:sc@imbi.uni-freiburg.de">sc@imbi.uni-freiburg.de</a>
Homepage: <a class="moz-txt-link-freetext" href="http://www.imbi.uni-freiburg.de">http://www.imbi.uni-freiburg.de</a>
</pre>
</body>
</html>