[R-meta] Correlation between two continuous outcome

[Reza Norouzian]

Hi Ishtiaque,

Can you possibly share a little more specifics about the dataset you are
working with? For example, how many studies do you have? How many of them
simultaneously studied the effect of X intervention on both pain intensity
and the several pain biomarkers of interest? Indeed, how many pain
biomarkers do you have and are there any that is/are not the focus of your
study?

Also, if you could share the structure of your data for a couple of studies
in a concise manner (ex. below), our list members could likely better
assist you.

Reza

study  SMD V   intensity   PDNF    . . . last_pain_biomarkers
1     .6  .1   number      number        number
1      1  .2   number      number        number
1     .9  .3   number      number        number
2     .7  .2   number      number        number
2     .8  .4   number      number        number



On Fri, Apr 19, 2024 at 10:30 AM Ishtiaq Ahmed via R-sig-meta-analysis <
r-sig-meta-analysis using r-project.org> wrote:

> Hi everyone,
> I hope everyone is doing well. My understanding of correlation
> meta-analysis is limited, and I'm seeking to enhance it. Currently, I'm
> conducting a meta-analysis to assess the effect of X intervention on both
> pain intensity and several pain biomarkers (such as BDNF, beta-endorphin,
> etc.) as compared with the control. I'm particularly interested in
> exploring the correlation between pain intensity and BDNF levels, both of
> which are continuous variables.
> I used escalc() to calculate the standardized mean difference (SMD) for
> pain intensity, considering the varying measurement scales between the
> intervention and control groups. Additionally, I've also calculated the
> mean difference (MD) for BDNF levels using the differences between the
> intervention and control groups.
> My question is whether it's possible to convert SMD/MD to correlation
> coefficient (r) to perform the correlation meta-analysis. Alternatively,
> are there other approaches to utilizing SMD and MD for this analysis?
> Additionally, some of the studies (though not all) have provided
> beta-values for the correlation between pain intensity and BDNF. Can I
> incorporate these beta-values into the meta-analysis?
>
> I would greatly appreciate any suggestions or sources you can provide.
>
>
>
> Best regards,
>
>
> Ishtiaq Ahmed
>
>
>
> Ph.D. Researcher
>
> Vrije Universiteit Brussels
>
>
>         [[alternative HTML version deleted]]
>
> _______________________________________________
> R-sig-meta-analysis mailing list @ R-sig-meta-analysis using r-project.org
> To manage your subscription to this mailing list, go to:
> https://stat.ethz.ch/mailman/listinfo/r-sig-meta-analysis
>

	[[alternative HTML version deleted]]