[R-meta] meta-analysis of ratios or difference of ratios?

[Martin Lobo]

Hello everyone. I'm Martin from Argentina. I am wanting to do a meta-analysis of the difference in means, baseline-final CRP drug vs pacebo. The problem is that complete data is not reported in most studies. Especially the standard deviation. What I have found is that they report the Final/baseline ratio in both groups. With these data you could calculate the difference in the ratios and their 95% CI. It is feasible to perform a meta-analysis with this data. My options would be meta-analysis of proportions (in this case I have the proportion but I don't know which one to use), perhaps another option would be the generic method of inverse variance where I would meta-analyze the difference in the proportions in both branches. Would any of these options be correct? Or can you tell me what would be the best method in this case? Thank you very much and happy holidays to all.




Lorenzo Mart�n Lobo MTSAC, FACC, FESC
Especialista Jerarquizado en Cardiolog�a
Jefe de Dpto Enf. Cardiovasculares y Cardiometabolismo Hospital Militar Campo de Mayo.
Jefe de Cardiolog�a Hospital Militar Campo de Mayo
Ex Jefe de Unidad Coronaria Hospital Militar Campo de Mayo
Miembro Titular de la Sociedad Argentina de Cardiolog�a
Fellow American College of Cardiology
Fellow European Society of Cardiology
Ex Miembro del Area de Investigaci�n de la SAC
Ex Director del Consejo de Aterosclerosis y Trombosis de la SAC
Miembro Asesor del Consejo de Aterosclerosis y Trombosis de la SAC
Ex Director del Consejo de Epidemiolog�a y Prevenci�n Cardiovascular de la SAC
Miembro Asesor del Consejo de Epidemiolog�a y Prevenci�n Cardiovascular de la SAC
Experto en Lipidos de la Sociedad Argentina de Lipidos.
Miembro de la Sociedad Argentina de Lipidos.
Instructor de ACLS de la American Heart Association


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