[R-meta] [netmeta] Error message in network meta-analysis: "Problem with multi-arm studies: Studies with inconsistent treatment estimates"
Rogasch, Rebecca Manuela Madeleine
@1rerog@ @end|ng |rom un|-tr|er@de
Sat Feb 22 18:22:49 CET 2020
Dear Wolfgang, dear Michael,
thanks so much for answering my question.
That helps a lot.
I really appreciate the kind Responses and clear explanations!
Thank you, Michael, for your advice on how to proceed!
I will follow your recommendations, thank you.
Best,
Rebecca
________________________________
Von: Michael Dewey <lists using dewey.myzen.co.uk>
Gesendet: Samstag, 22. Februar 2020 17:24:36
An: Rogasch, Rebecca Manuela Madeleine; Guido Schwarzer; r-sig-meta-analysis using r-project.org
Betreff: Re: [R-meta] [netmeta] Error message in network meta-analysis: "Problem with multi-arm studies: Studies with inconsistent treatment estimates"
Dear Rebecca
If the values you have transcribed are what it published then that
suggests, not for the first time, that a typo crept into the published
version. If you cannot contact the authors to clarify I would suggest
the error here is small and it is unlikely to makea substantive
difference if you increase the tolerance so that trial passes the check.
Michael
On 21/02/2020 18:54, Rogasch, Rebecca Manuela Madeleine wrote:
> Dear experts,
>
>
> first of all, I want to thank you again for your help!
>
> I am very thankful and really appreciate that you took time to answer my Questions.
>
> Dear Gerta R�cker, I apologize for the late Response, your Reply in the Mailing list hadn't reached me for some reason
>
> but was forwarded to me now.
>
>
> The Problem is Pretty much solved after entering the data in the Format you suggested.
>
>
> I no longer get an error for any of the nine 3-arm-studies, except for one - study "34".
>
>
> Output when applying "details.chkmultiarm":
>
>
> Multi-arm studies with inconsistent treatment effects:
> studlab treat1 treat2 TE resid
> 34 PE SIT -0.144613 0.00143599
> 34 PE WL -1.855309 -0.00143599
> 34 SIT WL -1.706388 0.00143599
> Legend:
> resid - residual deviation (observed minus expected)
> TE - treatment estimate
>
> I checked the data that I entered many, many times and compared it to the values in the paper.
>
> The values are correct, the data structure should be correct now.
>
>
> I am puzzled - and feeling a bit uncomfortable asking this last Question.
>
> But I am hoping that someone has an Explanation?
>
>
> Best regards,
>
> Rebecca
>
>
> ________________________________
> Von: Rogasch, Rebecca Manuela Madeleine
> Gesendet: Samstag, 8. Februar 2020 14:38:23
> An: Guido Schwarzer; r-sig-meta-analysis using r-project.org
> Betreff: AW: [R-meta] [netmeta] Error message in network meta-analysis: "Problem with multi-arm studies: Studies with inconsistent treatment estimates"
>
>
> Thank you very much for the quick Reply and your advice!
>
>
> That Explanation makes a lot of sense.
>
> I have now tried using pairwise() to calculate the SMDs:
>
>
> paired<- pairwise(list(TR1, TR2),
> n = list(n_TR1, n_TR2),
> mean = list(Mt2TR1, Mt2TR2),
> sd = list(SDt2TR1, SDt2TR2),
> data = DATA1, studlab = studlab, sm= "SMD")
>
>
>
> This is an exerpt from the data Frame;
>
> 3-arm study in Purple:
>
>
> studlab treat1 treat2 n1 mean1 sd1 n2 mean2 sd2 TE seTE age females severity income
> 1 1 EMDR WL 15 22.87 20.27 14 54.21 16.26 -1.65116388 0.4387386 36.54 0.76 clinical lowmid
> 44 100 NET WL 19 55.07 27.01 19 76.86 17.14 -0.94310177 0.3439769 29.40 0.31 clinical high income
> 45 104 NET PsEd 17 19.10 11.70 12 21.20 9.40 -0.18860625 0.3779770 32.85 0.62 clinical lowmid
> 48 107 MBI PsEd 68 46.90 18.20 66 55.20 15.30 -0.49022797 0.1754460 47.04 0.17 clinical high income
> 47 107 PE PsEd 68 50.60 18.50 66 55.20 15.30 -0.26905282 0.1735963 47.04 0.17 clinical high income
> 46 107 PE MBI 68 50.60 18.50 68 46.90 18.20 0.20049752 0.1719418 47.04 0.17 clinical high income
> 78 11 MBI WL NA NA NA NA NA NA -0.48920000 0.2800000 51.80 0.99 <NA> high income
>
> sample arms self_exp n_total tr_size analysis
>
> 1 refugees 2 self-rated 29 very small completers
> 44 refugees 2 clinician-rated 38 very small ITT
> 45 refugees 2 self-rated 29 very small ITT
> 48 vetmil 3 self-rated 134 large ITT
> 47 vetmil 3 self-rated 134 large ITT
> 46 vetmil 3 self-rated 136 large ITT
> 78 civilian 2 self-rated 71 small-moderate ITT
>
>
>
> However, I still get the same error message in the Network meta-Analysis.
>
> A more detailed copy of the Output is available if needed.
>
>
> Any advice is very much appreciated!
>
> Best regards,
>
> Rebecca
>
> ________________________________
> Von: Guido Schwarzer <sc using imbi.uni-freiburg.de>
> Gesendet: Freitag, 7. Februar 2020 17:49:50
> An: Rogasch, Rebecca Manuela Madeleine; r-sig-meta-analysis using r-project.org
> Betreff: Re: [R-meta] [netmeta] Error message in network meta-analysis: "Problem with multi-arm studies: Studies with inconsistent treatment estimates"
>
> Hi Rebecca,
>
> I assume the problem is related to calculating SMDs in multi-arm
> studies. Each pairwise comparison (in a multi-arm study) uses a
> different pooled standard deviation to calculate the SMD which leads to
> inconsistent effects.
>
> You could / should use pairwise() to calculate the SMDs which considers
> the same pooled standard deviation to calculate the SMD in multi-arm
> studies.
>
> Best wishes, Guido
>
> --
> Dr. Guido Schwarzer
> Institute of Medical Biometry and Statistics,
> Faculty of Medicine and Medical Center - University of Freiburg
>
> Postal address: Stefan-Meier-Str. 26, D-79104 Freiburg
>
> Phone: +49/761/203-6668
> Mail: sc using imbi.uni-freiburg.de
> Homepage: http://www.imbi.uni-freiburg.de
>
> ORCID iD: https://orcid.org/0000-0001-6214-9087
> R-book: https://www.springer.com/gp/book/9783319214153
>
>
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>
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--
Michael
http://www.dewey.myzen.co.uk/home.html
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