[R-meta] It is possible to calculate the Hazzard Ratio and 95% CI on different reference groups from summary available data?
Prof. Mario Petretta
petrett@ @end|ng |rom un|n@@|t
Tue Jul 2 17:55:48 CEST 2019
Dear mailing list members
I am doing a meta-analysis on the prognostic value of diastolic blood
pressure (BP).
A study reported the unadjusted hazard ratio (from Cox regression) for three
categories:
1) BP under 90 - hazard ratio 1 (reference)
2) BP 90 - 99 - hazard ratio 1.89 (95% CI 1.09, 3.33)
3) BP over 100 - hazard ratio 3.03 (95% 1.67, 5.56)
It is possible to combine these hazard ratios and the 95% confidence
intervals for three categories in two categories, considering together the
reference category and the second category as a new reference vs the third
category?
A more general question is: It is possible to convert hazard ratios and 95%
CI for 3 or more categories to a hazard ratio for 2 categories, changing the
reference category?
Thanks for your attention.
___________________________________________
Mario Petretta, MD, FAHA
Associate Professor of Internal Medicine
Department of Translational Medical Sciences
Naples University "Federico II" - Italy
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