[R-jobs] Post-doc in Systems Genetics, Gagneur lab, Munich

Julien Gagneur g@gneur @end|ng |rom genzentrum@|mu@de
Wed Jun 24 23:23:54 CEST 2015

Dear all,

we seek a talented and motivated post-doc to develop computational methods for inferring the molecular basis of genetic diseases by integration of personal omics data. Research topics include: identifying causal mutations of rare disease patients by meta-analysis; inferring disease-causing molecular pathways from genotype, phenotypes, and omics profile of patient-derived cell lines (transcritptomic, proteomic and metabolic). The developed methods will be applied to data from our collaborator Dr. Holger Prokisch, Institute of Human Genetics of Munich (cellular respiratory disorders) and will lead to functional validation studies directly on cell lines derived from patients.

The successful candidate will be part of SOUND, an international research project funded by the European Commission within its Horizon 2020 Research and Innovation programme �Personalizing Health and Care�. Its objective is to create the bioinformatic tools for statistically informed use of personal genomic and other �omic data in medicine, including cancers and rare metabolic diseases. It comprises partners from top research institutions including Cambridge, Munich, Zurich, Seattle, Heidelberg and Lisbon, and will run from September 2015 for 3 years.

Candidates must either hold a PhD in computational biology or bioinformatics, or hold a PhD in physics, statistics, or applied mathematics with practical experience with high-dimensional data analysis. Experience in quantitative genetics is a plus. Applicants must have a proven publication record and an interest for translational research.

The Gagneur lab is a young, lively, and multidisciplinary group with a research focus on systems genetics and gene regulation. It is located at the Gene Center of the LMU (University of Munich), an interdisciplinary institution whose 16 independent research groups investigate the regulation of gene expression at all levels - from the underlying molecular mechanisms to the biological system. The institute is located on the biomedical research campus Munich-Grosshadern, offering a dynamic, interactive and internationally oriented research environment. The dynamism of Munich and the proximity of the Alps provide an excellent quality of life.

The salary is according to the TV-L (German academic salary scale).

Applications including a cover letter, CV, and references must be sent to Julien Gagneur (gagneur using genzentrum.lmu.de) until July 31st 2015


Relevant references:
Gagneur et al., PLoS Genetics, 2013, Genotype-Environment Interactions Reveal Causal Pathways That Mediate Genetic Effects on Phenotype
Kornblum et al, Nature Genetics, 2013, Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease
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