To someone who could help me: I am a PhD student, working in the Wageningen University, the Netherlands. I am now using metafor package to do meta-analysis. Since there are few studies conducted on my topic, I have to combine the results from 5 case-control studies and 1 cohort study. But I do not know how to do it. I tried this way, first, use the escalc (measure="OR", ai, bi, ci, gi) to calculate the effect estimate of yi and variance of vi. I could extract the RR and 95% confidence interval from the cohort study to get the point estimate of LnRR and SE. but I can not combine the results from case-control study and the results from cohort study due to the difference of vi and SE. For example, if I use rma(yi, vi, data,), I can not get vi (variance) for the cohort study. I can only get SE for cohort study. How could solve it? Thanks for your time. Best wishes, Yingchang (Kevin) Lu PhD student, Division of Human Nutrition Wageningen University Tel: 0031-317-485300 Fax:0031-317-482782 http://www.hne.wur.nl/UK/Organisation/nutrition-metabolism-genomics [[alternative HTML version deleted]]