Dear all, I have one problem and did not find any solution. I have a file(file.txt) attached with this mail.I am reading it using this code to make a data frame (file)- file=read.table("file.txt",fill=T,colClasses = "character",header=T) file looks like this- Chr Pos CaseA CaseC CaseG CaseT 10 135344110 0.000000 24.000000 0.000000 0.000000 10 135344110 0.000000 0.000000 24.000000 0.000000 10 135344110 0.000000 0.000000 24.000000 0.000000 10 135344113 0.000000 0.000000 24.000000 0.000000 10 135344114 24.000000 0.000000 0.000000 0.000000 10 135344114 24.000000 0.000000 0.000000 0.000000 10 135344116 0.000000 0.000000 0.000000 24.000000 10 135344118 0.000000 24.000000 0.000000 0.000000 10 135344118 0.000000 0.000000 0.000000 24.000000 10 135344122 24.000000 0.000000 0.000000 0.000000 10 135344122 0.000000 24.000000 0.000000 0.000000 10 135344123 0.000000 24.000000 0.000000 0.000000 10 135344123 0.000000 24.000000 0.000000 0.000000 10 135344123 0.000000 0.000000 0.000000 24.000000 10 135344126 0.000000 0.000000 24.000000 0.000000 Now some of the values in column Pos are same.For these same positions i want to add the values of columns 3:6 I will explain with an example- The output of first row should be- Chr Pos CaseA CaseC CaseG CaseT 10 135344110 0.000000 24.000000 48.000000 0.000000 because first three rows have same value in Pos column. so the whole output for above input should be- Chr Pos CaseA CaseC CaseG CaseT 10 135344110 0.000000 24.000000 48.000000 0.000000 10 135344113 0.000000 0.000000 24.000000 0.000000 10 135344114 48.000000 0.000000 0.000000 0.000000 10 135344116 0.000000 0.000000 0.000000 24.000000 10 135344118 0.000000 24.000000 0.000000 24.000000 10 135344122 24.000000 24.000000 0.000000 0.000000 10 135344123 0.000000 48.000000 0.000000 24.000000 10 135344126 0.000000 0.000000 24.000000 0.000000 Can you please help me.