 

Two Postdoctoral fellows (fulltime) 

Leiden University, Leiden, The Netherlands

            

 

Job description 

________________________________________

TOP Institute Pharma (TI Pharma) has granted our proposal to set up a
mechanism-based PK-PD modelling platform. This platform focuses on the
transfer of knowledge from academia to the pharmaceutical industry and
is a collaborative effort of four academic partners and six industrial
partners. Unique to this platform is the availability of shared
databases on disease and drug related parameters.



The aim of the platform is to provide a scientific basis for rational
drug discovery and development with a strong focus on priority
medicines. Challenges are 1) to develop mechanism-based PKPD models to
characterise disease progression and to predict the effects of ageing on
clinical response and 2) to create a translational research framework
that allows extrapolation of preclinical to clinical and epidemiological
findings. Existing (pre-) clinical data will be analysed with advanced
data analysis software tools such as NONMEM and R.



We are looking for two highly motivated scientists (PhD degree) to:

1)         investigate disease models in COPD. The COPD project is part
of the disease progression working group which consist of two PhD
students and two post-doctoral research fellows. 

2)         evaluate the "operational" efficacy of drugs that have been
identified to produce QTc-interval prolongation in early clinical
development. The translational research working group will focus on
cardiovascular safety, schizophrenia and neuropathic pain. This working
group consists in total of six PhD students and two post-doctoral
fellows. 



Requirements 

________________________________________

The post-doctoral fellows should have the following background and
competencies:



*           A strong background in modelling & simulation and/or
Bayesian statistics 

*           A degree in Biostatistics, Medicine, Bioengineering,
Biopharmaceutical Sciences, Physiology or equivalent scientific training

*           Conceptual thinker

*           Problem-solving and coaching skills are essential

*           Ambitious

*           Creative

*           Interested to perform research in a unique multidisciplinary
setting



Organisation 

________________________________________

The Leiden Division of Pharmacology at the Leiden/Amsterdam Center for
Drug Research (LACDR) has a long-standing expertise in the development
of Pharmacokinetic/Pharmacodynamic (PKPD) models to predict efficacy and
safety of drugs. Given the nature of the disease, understanding of
statistical methodology (principal component analysis, multivariate
analysis, longitudinal and hierarchical models) is required for the
postdoc working on the COPD project. Knowledge of Bayesian concepts is
highly desirable. The main task of the post-doctoral fellow working on
the cardiovascular project will be to coach the PhD students, support
model building and simulation. Furthermore, he /she will be responsible
for the development of an overarching approach to link findings in early
and late clinical development.





Conditions of employment 

________________________________________

The employment for this position will be full time for at least 3 years.



Additional conditions of employment:

You will work as a team member of a TI Pharma project. The project team
comprises academic and industrial partners. In this case, the partners
are: universities of Leiden and Groningen, the University Medical Center
of Utrecht, the Erasmus Medical Center and the companies Eli Lilly,
Johnson & Johnson, GSK, Nycomed, Pfizer and Schering-Plough. You will
attend a unique drug discovery education and training program offered by
TI Pharma.

Additional Information 

________________________________________

For instance:



Additional information can be obtained through one of the following
links: 

http://www.lacdr.nl

Application ________________________________________You can apply by
sending your application to:

Contact person

Dr. O. Della Pasqua

Division of Pharmacology, Leiden/Amsterdam Center for Drug Research

Leiden, The Netherlands

odp72514@gsk.com 

+44 7876031907




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