
Post-Doctoral Fellowship 
Modelling of Cardiovascular Safety (full time)
Leiden University, Leiden, The Netherlands
 
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Job description 

TOP Institute Pharma (TI Pharma) has granted our proposal to set up a
mechanism-based PKPD modelling platform. This platform focuses on the
transfer of knowledge from academia to the pharmaceutical industry and
is a collaborative effort of four excellent academic institutes and six
leading global pharmaceutical industries. Unique to this platform is the
availability of shared databases on disease and drug related parameters.

The aim of the platform is to provide a scientific basis for rational
drug discovery and development with a strong focus on priority
medicines.  In total 11 PhD students and 7 post-doctoral fellows are
employed by the platform. Three working groups have been established
which will address the following challenges 1) to develop
mechanism-based PKPD models to characterise disease progression, 2) to
predict the effects of ageing on clinical response and 3) to create a
translational research framework that allows extrapolation of
preclinical to clinical and epidemiological findings. The approach is
based on hierarchical models and relies on the use of advanced
statistical software tools such as NONMEM, WINBUGS and R. 

To ensure the development of a conceptual research framework beyond the
specific scientific questions being addressed by the working groups and
enable cross-fertilisation of skills, a position has been created for a
post doctoral fellow.  The main objective of this program is to evaluate
how cardiovascular safety findings in phase III clinical trials
correlate to long term safety in longitudinal (epidemiology) studies.
From a methodological perspective, this investigation is aimed at
evaluating new parameterisations for drug exposure and integration of
PKPD concepts into the assessment of risk. 

Requirements 

The post-doctoral fellow should have the following background and
competencies:

*	A strong background in statistical modelling & simulation and/or
Bayesian statistics
*	A degree in Biostatistics, Epidemiology, Medicine,
Biopharmaceutical Sciences, Physiology or equivalent scientific training
*	Bird eyes'  view
*	Conceptual thinker
*	Problem-solving and coaching skills are essential
*	Ambitious
*	Creative
*	Interested to perform research in a unique multidisciplinary
setting

Organisation 

The Leiden Division of Pharmacology at the Leiden/Amsterdam Center for
Drug Research (LACDR) has a long-standing expertise in the development
of Pharmacokinetic/Pharmacodynamic (PKPD) models to predict efficacy and
safety of drugs. Given the nature of this project, the main task of the
principal post-doctoral fellow will be to coach the PhD students and
postdocs within the platform, to support model building and simulation
and to identify underlying general principles shared among individual
projects. 

Conditions of employment 

The employment for this position will be full time for 4 years.

Additional conditions of employment:
You will work as a team member of a TI Pharma project. The project team
comprises academic and industrial partners. In this case, the partners
are: University of Leiden, University of Groningen, the University
Medical Center of Utrecht, the Erasmus Medical Center, Rotterdam and the
companies Eli Lilly, Johnson &  Johnson, GSK, Nycomed, Organon/Schering
Plough and Pfizer. You will attend a unique drug discovery education and
training program offered by TI Pharma.
Additional Information 

Additional information can be obtained through one of the following
links: 
http://www.lacdr.nl
Application You can apply by sending your application to:
Contact person
Dr. O. Della Pasqua
Division of Pharmacology, Leiden/Amsterdam Center for Drug Research
Leiden, The Netherlands
Odp72514@gsk.com 
+44 7876031907



Margot Beukers, PhD 
Project Manager
TI Pharma PK PD Modeling Platform
Availability (CET):
Monday: 12.30 - 16.30
Wednesday: 07.30 -16.30
Thursday: 07.30 -11.30
Friday: 12.30 - 16.30
 
Gorlaeus Laboratories, HB811, Leiden University
Einsteinweg 55
2333 CC, Leiden, The Netherlands
Email: beukerspkpd AT lacdr DOT leidenuniv DOT nl
<mailto:beukerspkpd@lacdr.leidenuniv.nl> 
Tel: +31-71-5276276


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