Dear all,

 

Should you be interested in a career at our mechanism-based PK-PD
modeling platform, please read the remainder of this message.

 

Best wishes, 
Margot Beukers

 

Unique PK-PD modeling platform established in 

The Netherlands

 

Are you our ambitious IT platform manager

with a profound drive to contribute to a new era of drug research? 

 

 

PK-PD modeling platform

Prof. dr. Meindert Danhof heads the "TI Pharma mechanism-based PK-PD
modeling platform". Our unique platform will house a shared database for
the purpose of mechanism-based PK-PD model building. As underscored in
the Critical Path to New Medicines report by the FDA, our models are
essential to revert the current attrition rate of new drugs and will
result in less in vivo testing, increase effectiveness of clinical
trials and will assist clinicians in the treatment of progressive
diseases and of vulnerable patients such as children. This public
private research partnership is a collaborative effort of four
outstanding Dutch academic partners: the University of Leiden, the
University of  Groningen, the University Medical Center of Utrecht, the
Erasmus Medical Center (Rotterdam) and six leading global pharmaceutical
companies: Eli Lilly, Johnson & Johnson, GSK, Nycomed, Organon/Schering
Plough and Pfizer.

 

Our Challenge

Our platform focuses on rational drug discovery through the development
of PK-PD models. We aim to:

1)     Create a translational research framework for the extrapolation
of preclinical to clinical and epidemiological findings.

2)     Predict the effects of ageing on the clinical response to
essential drugs.

3)     Develop mechanism-based PK-PD models to characterize and predict
disease progression.

 

The establishment of the repository containing the (pre-) clinical data
from the individual partners is essential to address the cutting-edge
clinical and scientific questions which center around priority medicines
as defined by WHO.

 

IT Platform Manager

The core of the platform consists of the data management system. This
secure system houses all individual as well as merged datasets. It
enables the 11 PhD students and 7 post-doctoral fellows to create their
mathematical PK-PD models, which are also stored in this secure system.
We offer you as IT Platform Manager a unique opportunity to exploit your
scientific talents and to expand your communications- and management
skills, on the exciting interface of medical science and IT. You will be
responsible for the IT Platform and as key player maintain all essential
contacts among the consortium research fellows and researchers from
academia and industry to guarantee a smooth operation of the facility.

 

Background and competencies

*	Experienced in (bio)medical data management  
*	Familiar with the Linux environment, SAS and/or R 
*	Ability to prioritize and to keep your focus in a cross-cultural
environment
*	Excellent communicator
*	Networking skills
*	Problem-solving
*	Attentive
*	Accurate
*	Enterprising
*	Creative

 

Setting

You will be based at Leiden University, the first and most prestigious
university in the Netherlands which was founded in February 1575, as a
gift from William of Orange to the citizens of Leiden who had withstood
a long siege by the Spaniards. Leiden, the place where Rembrandt was
born, is a bustling city with a beautifully preserved historical center
providing excellent international schools. Among 32 European
Universities, Leiden University was ranked number 1 by international
students for its international orientation. Amsterdam Airport can be
reached in 15 train minutes   .

 


About TI Pharma 


Within TI Pharma (www.tipharma.com), consortia of industrial and
academic research teams conduct groundbreaking, cross-disciplinary
research projects that fit into the Priority Medicines program of the
WHO. Each year, the Dutch government funds the top institute to a tune
of 30 million Euros. The pharmaceutical industry and academia each
contribute an additional 15 million Euros per year. TI Pharma is
becoming an international leader in (bio)pharmaceutical research,
training and education. TI Pharma's fellows are trained in understanding
the intricacies of the entire drug R&D process.

 

If you are interested to hear more about this position please contact
our project manager Dr. Margot Beukers: beukerspkpd@lacdr.leidenuniv.nl

 

 


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