I came across a post by Karl Knoblick regarding the modeling of longitudinal data (see https://stat.ethz.ch/pipermail/r-help/2007-May/132137.html).  I am often asked by physicians to perform what Karl refers to in his post as option 1: to perform paired t-tests against baseline at each follow up time point (30 days, 90 days, 6 months, etc.).  Unlike Karl's example, however, many of the trials I am involved in are one-armed (so there are no across-trial-arms comparisons).

No matter how hard I try to explain to physicians why this approach is not the best, it has typically been to no avail.  I am wondering if anyone knows of a paper I can quote instead?  One (or more) from the cardiovascular literature would be especially precious to me.

Best regards,
   -Cody Hamilton



	[[alternative HTML version deleted]]

