Dear Jesus

It is possible with nlmeODE. Check out the example ?PKPDpool where PK and PD
are fitted simultaneously.

Best regards

Christoffer

> Now, I am including Richar Upton's 2 cm model implementation and 
> Christoffer Tornoe's nls solution (I recommend Christoffer's nlmeODE 
> package for these problems also if multi-response data is
> available) The code follows:

>Multi-response data?, Is there a way of dealing with those multiresponse
nonlinear regression problems in R (a la Chapter 4 of Bates and Watts, if
>>possible)?, the only alternative I heard of was in a mail from Douglas
Bates, using optim() and the definition of the Box-Drapper criterion,

> prod(svd(y-f(p1,p2,p3), nu=0, nv=0)$d)^2

>if you wish to minimize a matrix of y's in respect to p1,p2 and p3.


best regards,

Jesus


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