[R] Comparing summary hazard ratios in meta-analysis

Mario Petretta petretta at unina.it
Fri Nov 21 09:51:48 CET 2014

Dear all,

I use R 3.1.1 for Windows.

I performed two different meta-analysis assessing the prognostic value of
two different tests in patients with coronary artery disease. The study
included in the two analysis are different.

The variable of interest in dichotomous (normal/abnormal result) for both
The effects size is hazard ratio and its standard error (ln units) for both

I would like to statistically compare the two summary hazard ratios and 95%
CI (eform) obtained from the two meta-analysis.

For one meta-analysis: HR 3.12 (95% CI 2.2 - 4.1)
For the other: HR 1.25 (95% CI 1.03 - 2.6) 

It is possible or I'm comparing apples with oranges?

Any suggestion is welcome.

Mario Petretta
Associate Professor of Internal Medicine
Department of Translational Medical Sciences Naples
University Federico II Italy

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