[R] Dose-response relationship using metafor?

[Viechtbauer Wolfgang (STAT)]

Can you provide a minimal and self-contained example showing/illustrating what you have done and would like to test? Based on the information provided, I could only make a vague suggestion along the lines of: You could include dose in an appropriate meta-regression model and then examine whether polynomial versions of the dose variable are significant (which would suggest a non-linear relationship).

Best,
Wolfgang

--   
Wolfgang Viechtbauer, Ph.D., Statistician   
Department of Psychiatry and Psychology   
School for Mental Health and Neuroscience   
Faculty of Health, Medicine, and Life Sciences   
Maastricht University, P.O. Box 616 (VIJV1)   
6200 MD Maastricht, The Netherlands   
+31 (43) 388-4170 | http://www.wvbauer.com   


> -----Original Message-----
> From: r-help-bounces at r-project.org [mailto:r-help-bounces at r-project.org]
> On Behalf Of Ross, Stephanie
> Sent: Wednesday, September 18, 2013 21:41
> To: r-help at r-project.org
> Subject: [R] Dose-response relationship using metafor?
> 
> I am currently working a meta-analysis that is exploring the effect of a
> drug on plasma lipid levels. However, I am primarily interested in
> assessing the overall dose-response relationship with mean change in
> lipids. I have used the metafor package to conduct a meta-regression but
> is there a way to determine if this relationship is linear? Something like
> a p-value for trend?
> Thanks so much!
> 
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