[R] Heatmap with error message: `x' must be a numeric matrix

Rui Barradas ruipbarradas at sapo.pt
Tue Jun 25 21:51:20 CEST 2013


Hello,

Your data has commas as decimal points, R uses the period. So the data 
is read in as strings, not numbers. You can change this by using 
argument 'dec' of read.table:

?read.table
read.table(...etc..., dec = ",")


Or you can replace the commas with periods:


data[] <- sapply(data, function(x) as.numeric(sub(",", "\\.", x)))

data1 <- as.matrix(data)
heatmap.2(...)  # No errors


Hope this helps,

Rui Barradas

Em 25-06-2013 19:49, Gitte Brinch Andersen escreveu:
> Hi
>
> I am trying to do a heatmap, but I can't see what I am doing wrong. I get the error message: `x' must be a numeric matrix, but as far as I know I have changed my data into a matrix.
>
> The dataset I have in my example of my run is only a small part. I have around 1000 rows in total. I have checked that none of the rows contains any letters etc, and I have removed the rows where some of the samples contain NA. So I can't see why the numbers aren't numeric.
>
> I have tried to change the numbers to contain dots instead of commas, but this still gives me the same error.
>
> I hope someone can give me a hint to what I am doing wrong!
>
> I am still very new to R, and apologize in advance if this is just some simple stupid mistake.
>
> My R run is this:
>
> #Load in data
>> data<-read.table("/Users/gban/Desktop/Probes_for_heatmap_35_meth_diff_both_hypo_and_hypermeth_Gene&probenames.txt",sep="\t",header=TRUE,row.names=1)
>
>
>
> # Throw out rows with missing values.
>> data = na.omit(data)
>
>
>
>> data
>                                    OS_Tumor1_08_14985_2_3 OS_Tumor2_08_226869_1
> CHST3_cg04268405_1                           0,950380605            0,76433753
> DLX5_cg19962750_2                             0,93111825           0,753845234
> ZIC4_cg12892506_3                            0,860337466           0,696149332
> DLX5_cg05597836_4                            0,906981714           0,664148911
> ARHGEF7_cg09129334_6                          0,88102921           0,726231077
> ZIC4_cg02387803_7                            0,770987986           0,568085839
> ZIC4_cg05855917_8                            0,880514891           0,681148663
> DLX5_cg13286614_9                            0,855132688           0,592368469
> ZIC4_cg04556126_10                           0,907405655           0,718858033
> LOC145845_cg25718467_11                      0,893492688           0,793191968
> ZIC4_cg08393041_12                           0,911133787           0,678042743
> SNED1_cg03785076_13                          0,862060883            0,70294155
> C10orf116_cg01004363_14                      0,858555164           0,553920222
> DLX5_cg20250426_15                           0,903165828            0,64976206
> EPHX3_cg16184495_16                          0,927538308           0,519523714
> SNED1_cg21304158_17                          0,762270611           0,647588457
> EN1_cg12418535_19                            0,790529679           0,318880892
> RTKN_cg00689340_20                           0,941714187           0,675243565
> SNED1_cg16937168_21                          0,894421593           0,821448724
> CD93_cg12873119_22                            0,86949625           0,676389091
> RRN3P2_cg00525931_23                         0,862670615           0,855822961
> GPBAR1_cg18581950_24                         0,800216557           0,810012301
> SPARCL1_cg15552249_25                        0,815666773           0,837099021
> HOXD12_cg23130254_26                         0,840109076           0,502896181
> ZIC4_cg08889797_27                           0,779606392           0,591615859
> ESRP2_cg06723863_28                          0,655488067            0,47819514
> ZIC4_cg16790847_29                           0,735676228           0,611372155
> PFDN5_cg16309127_30                          0,753348167           0,630504254
> ARHGEF7_cg05776861_31                        0,951737748           0,926613919
> TBX15_cg24720355_32                          0,906521431           0,364984479
> FER1L5_cg01876130_33                         0,601084686           0,805388591
> HOXD12_cg18022224_34                         0,865974739           0,543178066
> DLX6AS_cg26251506_35                         0,804479354           0,538022928
> GSTM5_cg05376982_36                          0,733426641           0,552089202
> ZIC4_cg12976081_37                           0,464939006           0,551218578
> HOXB4_cg02132714_38                          0,798491712           0,718121432
> HOXD10_cg17489939_39                         0,970868858           0,790134913
> C10orf116_cg12261786_40                      0,727394677           0,573072856
> SPARCL1_cg19466563_41                         0,79754226           0,722582785
> HOXD12_cg03964958_42                         0,778450531           0,679889139
> HOXA5_cg09549073_43                            0,4652904           0,377825589
> ZIC4_cg00334063_44                           0,783052842           0,634682328
> TBX15_cg16990168_45                          0,893463329           0,235197972
>
> #Load gplot package
>> library(gplots)
>
> #Make the data into a matrix
>> data1<-as.matrix(data)
>
>> data1
>
>                                    OS_Tumor1_08_14985_2_3 OS_Tumor2_08_226869_1
> CHST3_cg04268405_1                "0,950380605"          "0,76433753"
> DLX5_cg19962750_2                 "0,93111825"           "0,753845234"
> ZIC4_cg12892506_3                 "0,860337466"          "0,696149332"
> DLX5_cg05597836_4                 "0,906981714"          "0,664148911"
> ARHGEF7_cg09129334_6              "0,88102921"           "0,726231077"
> ZIC4_cg02387803_7                 "0,770987986"          "0,568085839"
> ZIC4_cg05855917_8                 "0,880514891"          "0,681148663"
> DLX5_cg13286614_9                 "0,855132688"          "0,592368469"
> ZIC4_cg04556126_10                "0,907405655"          "0,718858033"
> LOC145845_cg25718467_11           "0,893492688"          "0,793191968"
> ZIC4_cg08393041_12                "0,911133787"          "0,678042743"
> SNED1_cg03785076_13               "0,862060883"          "0,70294155"
> C10orf116_cg01004363_14           "0,858555164"          "0,553920222"
> DLX5_cg20250426_15                "0,903165828"          "0,64976206"
> EPHX3_cg16184495_16               "0,927538308"          "0,519523714"
> SNED1_cg21304158_17               "0,762270611"          "0,647588457"
> EN1_cg12418535_19                 "0,790529679"          "0,318880892"
> RTKN_cg00689340_20                "0,941714187"          "0,675243565"
> SNED1_cg16937168_21               "0,894421593"          "0,821448724"
> CD93_cg12873119_22                "0,86949625"           "0,676389091"
> RRN3P2_cg00525931_23              "0,862670615"          "0,855822961"
> GPBAR1_cg18581950_24              "0,800216557"          "0,810012301"
> SPARCL1_cg15552249_25             "0,815666773"          "0,837099021"
> HOXD12_cg23130254_26              "0,840109076"          "0,502896181"
> ZIC4_cg08889797_27                "0,779606392"          "0,591615859"
> ESRP2_cg06723863_28               "0,655488067"          "0,47819514"
> ZIC4_cg16790847_29                "0,735676228"          "0,611372155"
> PFDN5_cg16309127_30               "0,753348167"          "0,630504254"
> ARHGEF7_cg05776861_31             "0,951737748"          "0,926613919"
> TBX15_cg24720355_32               "0,906521431"          "0,364984479"
> FER1L5_cg01876130_33              "0,601084686"          "0,805388591"
> HOXD12_cg18022224_34              "0,865974739"          "0,543178066"
> DLX6AS_cg26251506_35              "0,804479354"          "0,538022928"
> GSTM5_cg05376982_36               "0,733426641"          "0,552089202"
> ZIC4_cg12976081_37                "0,464939006"          "0,551218578"
> HOXB4_cg02132714_38               "0,798491712"          "0,718121432"
> HOXD10_cg17489939_39              "0,970868858"          "0,790134913"
> C10orf116_cg12261786_40           "0,727394677"          "0,573072856"
> SPARCL1_cg19466563_41             "0,79754226"           "0,722582785"
> HOXD12_cg03964958_42              "0,778450531"          "0,679889139"
> HOXA5_cg09549073_43               "0,4652904"            "0,377825589"
> ZIC4_cg00334063_44                "0,783052842"          "0,634682328"
> TBX15_cg16990168_45               "0,893463329"          "0,235197972"
>
> heatmap.2(data1, col=redgreen(75), scale="row", key=T, keysize=1.5,density.info="none", trace="none",cexCol=0.9, labRow=NA)
> Fejl i heatmap.2(data1, col = redgreen(75), scale = "row", key = T,  :
>    `x' must be a numeric matrix
>
> Many thanks!
>
> Kind regards
>
> Gitte Brinch Andersen
>
>
> 	[[alternative HTML version deleted]]
>
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