[R] How to calculate correlation matrix for 128 * 12625 matrix

[mahdi]

In our dataset the samples/object are number of patients which is 128 and we
are dealing with 12,625 genes which is our
attributes of the dataset. So, it is obvious that if I calculate the
correlation matrix of (128 * 12,625) the resulted dimension of the
correlation matrix will be (12,625 * 12,625). I need some help about this
calculation.

1. How I can make the transpose matrix of 12625 * 128  to 128 * 12625.
Suppose I have written t(x) where x is a matrix of 12625 * 128. But after
giving the command t(x) when I write x to see then I saw it has not been
changed to 128 * 12625.

2. it is obvious that if I calculate the correlation matrix of (128 *
12,625) the resulted dimension of the correlation matrix will be (12,625 *
12,625). But I think this 12625 is huge to work with.....so is there any
solution for that? What should I do now?

Thanks in advance. Take care.

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