[R] How to compute boundaries for bivariate normal distribution in group sequential design

[jeka12386]

Hi all

Dear all, 
I need to compute boundaries for 3 stages group sequential design with 2
variables using Simpson’s integration method. 
There is a r program written by Michael A. Proschant et Al. (2006)
(Statistical Monitoring of Clinical Trials: A Unified Approach) – see file
attached – to calculate boundaries for 1 variable only. 
Does anyone know how this program can be modified to incorporate a second
variable? Or propose an alternative solution please?

Many thanks 

Jeka

http://r.789695.n4.nabble.com/file/n4632450/Boundary.R Boundary.R 

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