[R] Help with modFit of FME package

Paola Lecca pllcc023 at gmail.com
Thu Jul 28 16:53:11 CEST 2011

Dear R users,

I’m trying to fit a set an ODE to an experimental time series. In the
attachment you find the R code I wrote using modFit and modCost of FME
package and the file of the time series.

When I run summary(Fit) I obtain this error message, and the values of the
parameters are equal to the initial guesses I gave  to them.

The problem is not due to the fact that I have only one equation (I tried
also with more equations, but I still obtain this error).

I would appreciate if someone could help me in understanding the reason of
the error and in fixing it.

Thanks for your attention,


Here the error:

> summary(Fit)


              Estimate Std. Error t value Pr(>|t|)

pro1_strength        1         NA      NA       NA

Residual standard error: 2.124 on 10 degrees of freedom

Error in cov2cor(x$cov.unscaled) : 'V' is not a square numeric matrix

In addition: Warning message:

In summary.modFit(Fit) : Cannot estimate covariance; system is singular

*Paola Lecca, PhD*
*The Microsoft Research - University of Trento*
*Centre for Computational and Systems Biology*
*Piazza Manci 17 38123 Povo/Trento, Italy*
*Phome: +39 0461282843*
*Fax: +39 0461282814*
-------------- next part --------------
time	pp1_mrna	
0	0
2	2.754
4	2.958
6	4.058
8	3.41
10	3.459
12	2.453
14	1.234
16	2.385
18	3.691
20	3.252

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