[R] help mkin

[rebekka baumgartner]

Hi,
I am trying fit my kinetic data with the "mkin" package. There I have two questions:

1.) I would like to fix the parameter parent_0, the concentration of the parent at time 0. In the mkinfit function description it says you can do it with the arguments parms.ini and fixed_parms. In which form do these arguments have to be to fix the (internally defined and fitted) parameter parent_0?
SFO <- mkinmod(parent=list(type="SFO"))
SFO.fit <- mkinfit(SFO,data, parm.ini=??, fixed_parms=??)

2.) When I try to fit the parent and a metabolite m1, I get the error message:
Error in dnorm(x, mean, sd, log) : 
  Non-numeric argument to mathematical function
In addition: Warning messages:
1: In Ops.factor(ModVar, obsdat) : - not meaningful for factors
2: In Ops.factor(ModVar, obsdat) : - not meaningful for factors

My code is:
data <- read.table("101025_batch1.txt", header=TRUE)
SFO_SFO <- mkinmod(parent = list(type = "SFO", to = "m1", sink =TRUE),m1 = list(type = "SFO")) 
SFO.fit <- mkinfit(SFO_SFO,data)

101025_batch1.txt looks like this:
name	time	value
parent	0	NA
parent	15	NA
parent	29	23.796
parent	44	14.499
parent	58	7.650
parent	73	4.170
parent	88	2.438
parent	102	1.865
parent	117	1.598
m1	0	0
m1	15	6.476
m1	29	19.651
m1	44	32.271
m1	58	40.906
m1	73	48.295
m1	88	53.295
m1	102	56.250
m1	117	58.459

Thank you very much for you help!
Rebekka
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