[R] Pharmacokinetic and pharmacodynamic modeling and simulation

[Dick Verkerk]

  Pharmacokinetic and pharmacodynamic modeling and simulation
  By Dr. Jan Freijer
  March 18, 2010
  Amsterdam, The Netherlands

  http://www.can.nl/events/details.php?id=57

  This course is aimed at users of R or S-PLUS in the bio-pharmaceutical
  sciences who would like to use R for clinical trial simulations.

  topics include

  Working with packages in R
  - MASS
  - odesolve

  Random generation from univariate distributions
  - density, distribution function, quantile function and random generation
  - various distributions

  Random generation from multivariate distributions
  - normal distribution
  - working with the covariance matrix
  - simulating PK and PK-PD model parameters

  Solving differential equations
  - solving differential equations in R
  - testing the numerical solution versus analytical solution
  - PK models for single dose oral or IV administration
  - PK models for multiple dose oral or IV administration
  - implementing PD models

  Clinical trial simulations
  - combining the structural model with the random effects model
  - uncertainty versus variability
  - example: two compartment PK model with indirect response model


  Location:  Amsterdam
  Date    :  March 18th
  Time    :  10:00h.-16:30h.
  Price   :  EURO 395,- excluding VAT

  Register:
  - phone : +31-(0)20-560-8400
  - Email : paulus at can.nl
  - Web   : http://www.can.nl/events/details.php?id=57

  There is a maximum of 12 participants.

  You may register by replying to this email and provide us with the
  following information.

  Name       :                      M / F
  Title      :
  Department :
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  Address    :
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  Please let us know if you have any questions.

  Please feel free to send this message on to your colleagues and friends
  for whom it might be interesting!!

  Kind regards,

  Dick Verkerk


  _________________________

  CANdiensten, Nieuwpoortkade 23-25, NL-1055 RX Amsterdam
  tel: +31 20 5608410 fax: +31 20 5608448 verkerk at candiensten.nl
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