[R] Pharmacokinetic and pharmacodynamic modeling and simulation

[Dick Verkerk]

   Pharmacokinetic and pharmacodynamic modeling and simulation
   By Dr. Jan Freijer
   September 24, 2009
   Amsterdam, The Netherlands

   http://www.can.nl/events/details.php?id=57

   This course is aimed at users of R or S-PLUS in the bio-pharmaceutical
   sciences who would like to use R for clinical trial simulations.

   topics include

   Working with packages in R
   - MASS
   - odesolve

   Random generation from univariate distributions
   - density, distribution function, quantile function and random generation
   - various distributions

   Random generation from multivariate distributions
   - normal distribution
   - working with the covariance matrix
   - simulating PK and PK-PD model parameters

   Solving differential equations
   - solving differential equations in R
   - testing the numerical solution versus analytical solution
   - PK models for single dose oral or IV administration
   - PK models for multiple dose oral or IV administration
   - implementing PD models

   Clinical trial simulations
   - combining the structural model with the random effects model
   - uncertainty versus variability
   - example: two compartment PK model with indirect response model


   Location:  Amsterdam
   Date    :  September 24
   Time    :  10:00h.-16:30h.
   Price   :  EURO 395,- excluding VAT

   Register:
   - phone : +31-(0)20-560-8400
   - Email : paulus at can.nl
   - Web   : http://www.can.nl/events/details.php?id=57

   There is a maximum of 12 participants.

   You may register by replying to this email and provide us with the
   following information.

   Name       :                      M / F
   Title      :
   Department :
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   Please let us know if you have any questions.

   Please feel free to send this message on to your colleagues and friends
   for whom it might be interesting!!

   Kind regards,

   Dick Verkerk


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   CANdiensten, Nieuwpoortkade 23-25, NL-1055 RX Amsterdam
   tel: +31 20 5608410 fax: +31 20 5608448 verkerk at candiensten.nl
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