[R] Adjusting confidence intervals for paired t-tests of multiple endpoints

[Erich Studerus]

Thanks, this comes close to what I need, but the problem is that I have
repeated measures in each comparison and SimComp does not seem to handle
this. In my experiments, each subject received both placebo and the drug in
a randomized order. So, I want to do multiple paired t-test corrected for
multiple comparisons. I'm primarily interested in the corrected confidence
intervals because I want to plot the mean differences with it.

Regards,
Erich

  

-----Ursprüngliche Nachricht-----
Von: r-help-bounces at r-project.org [mailto:r-help-bounces at r-project.org] Im
Auftrag von Mark Difford
Gesendet: Montag, 2. März 2009 08:34
An: r-help at r-project.org
Betreff: Re: [R] Adjusting confidence intervals for pairedt-tests of
multiple endpoints


Hi Erich,

Look at the SimComp package, which handles multiple endpoints, i.e. columns
of response variables. Ratio-comparisons are also handled. Good ready-made
range of comparisons; you can also set up your own.

Regards, Mark.


Erich Studerus wrote:
> 
>   Johannes Huesing <johannes at huesing.name> wrote:
>> Couldn't you re-phrase your model by including timepoint as a continuous 
>> regressor and scale as a factor?
> 
> Well, the measuring time points are 70 170, 300 and 1440 minutes after
> drug 
> intake. Since the influence of time is cerainly not linear, I think it's 
> better to treat it as categorical factor. In fact, I already calculated 
> mixed effects models with the four-level factor time and the two-level 
> factor treatment and random effects factors subjects (nested in studies)
> and 
> studies for each scale. I used mixed effects models, because I'm doing a 
> meta-analysis on the raw data of 8 studies. Thus my dataset has not only a

> grouping structure, but is also unbalanced (not all studies did 4 
> measurements). I'm not sure, if I could extend my model by including
> another 
> factor for scale, since these scales measure quite different things. I 
> guess, It would be also very difficult the set up appropriate contrasts to

> compare each scale on each measuring time point.
> 
> ______________________________________________
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