[R] Pharmacokinetic and pharmacodynamic modeling and simulation

[Dick Verkerk]

    Pharmacokinetic and pharmacodynamic modeling and simulation
    By Dr. Jan Freijer
    September 24, 2009
    Amsterdam, The Netherlands

    http://www.can.nl/events/details.php?id=57

    This course is aimed at users of R or S-PLUS in the bio-pharmaceutical
    sciences who would like to use R for clinical trial simulations.

    topics include

    Working with packages in R
    - MASS
    - odesolve

    Random generation from univariate distributions
    - density, distribution function, quantile function and random generation
    - various distributions

    Random generation from multivariate distributions
    - normal distribution
    - working with the covariance matrix
    - simulating PK and PK-PD model parameters

    Solving differential equations
    - solving differential equations in R
    - testing the numerical solution versus analytical solution
    - PK models for single dose oral or IV administration
    - PK models for multiple dose oral or IV administration
    - implementing PD models

    Clinical trial simulations
    - combining the structural model with the random effects model
    - uncertainty versus variability
    - example: two compartment PK model with indirect response model


    Location:  Amsterdam
    Date    :  September 24
    Time    :  10:00h.-16:30h.
    Price   :  EURO 395,- excluding VAT

    Register:
    - phone : +31-(0)20-560-8400
    - Email : paulus at can.nl
    - Web   : http://www.can.nl/events/details.php?id=57

    There is a maximum of 12 participants.

    You may register by replying to this email and provide us with the
    following information.

    Name       :                      M / F
    Title      :
    Department :
    Institute  :
    Address    :
    City       :
    Zip        :
    Telephone  :
    Fax        :
    Email      :

    Please let us know if you have any questions.

    Please feel free to send this message on to your colleagues and friends
    for whom it might be interesting!!

    Kind regards,

    Dick Verkerk


    _________________________

    CANdiensten, Nieuwpoortkade 23-25, NL-1055 RX Amsterdam
    tel: +31 20 5608410 fax: +31 20 5608448 verkerk at candiensten.nl
    _________________________
    Your Partner in Mathematics and Statistics!