[R] Adjusting confidence intervals for paired t-tests of multiple endpoints

[Dieter Menne]

Erich Studerus <erich.studerus <at> bli.uzh.ch> writes:

> 
> 
> Dear R-users,
> 
> In a randomized placebo-controlled within-subject design, subjects recieved
> a psycho-active drug and placebo. Subjects filled out a questionnaire
> containing 15 scales on four different time points after drug
> administration. In order to detect drug effects on each time point, I
> compared scale values between placebo and drug for all time conditions and
> scales, which sums up to 4*15=60 comparisons.
> 
....
> Now, I want to adjust the confidence intervals for multiple comparisons.

For simple cases, see p.adjust or TukeyHSD (more limited).

For complex cases, see simint and friends in package multcomp.

Dieter