[R] SPLUS Seqtrial vs. R Packages for sequential clinical trials designs

David Freedman 3.14david at gmail.com
Thu Dec 17 18:34:50 CET 2009

You'll probably want to take a look at the CRAN Task View, 

david freedman

Paul Miller wrote:
> Hello Everyone,
> I’m a SAS user who has recently become interested in sequential clinical
> trials designs. I’ve discovered that the SAS based approaches for these
> designs are either too costly or are “experimental.” So now I’m
> looking for alternative software. Two programs that seem promising are
> SPLUS Seqtrial and R.
> I recently obtained a 30 day trial for the SPLUS Seqtrial add-on and have
> worked my way through most of the examples in the manual. I’ve also
> gotten access to R, installed a package called gsDesign, and worked
> through most of the examples in its documentation. 
> Although I don’t yet have a good understanding of the various approaches
> to sequential clinical trials designs, I thought that the gsDesign package
> seemed very impressive. I also understand that there are several other R
> packages that relate to sequential clinical trials designs, such as
> AGSDest , GroupSeq, ldbounds, MChtest, PwrGSD, and Seqmon. Some of these
> seem fairly comprehensive while others seem to focus on a single approach. 
> My questions center on the adequacy of SPLUS Seqtrial and the R Packages.
> I was wondering if there is anyone out there who would be familiar enough
> with these to comment on their relative merits. Will SPLUS Seqtrial or the
> R packages allow me to do all the designs I’m ever likely to need? If I
> pay for SPLUS Seqtrial, will I get anything that I can’t get using the
> various R packages? Are any of the R packages comprehensive? Or would it
> at least be possible to cover all the types of designs that are commonly
> used by employing a variety of R packages? What kind of validation work
> generally goes into an R package and how would this likely compare to the
> sort of validation work that has gone into Seqtrial?
> There may be other questions that I should be asking but haven’t thought
> of. 
> At any rate, if some of you would be willing to share some advice or
> insights I’d greatly appreciate it.
> Thanks,
> Paul
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