[R] SPLUS Seqtrial vs. R Packages for sequential clinical trials designs
3.14david at gmail.com
Thu Dec 17 18:34:50 CET 2009
You'll probably want to take a look at the CRAN Task View,
Paul Miller wrote:
> Hello Everyone,
> Iâm a SAS user who has recently become interested in sequential clinical
> trials designs. Iâve discovered that the SASÂ based approaches for these
> designs are either too costly or areÂ âexperimental.â So now Iâm
> looking for alternative software. Two programs that seem promising are
> SPLUS Seqtrial and R.
> I recently obtained a 30 day trial for the SPLUS Seqtrial add-on and have
> worked my way through most of the examples in the manual. Iâve also
> gotten access to R, installed a package called gsDesign, and worked
> through most of the examples in its documentation.
> Although I donât yet have a good understanding of the various approaches
> to sequential clinical trials designs, I thought that the gsDesign package
> seemed very impressive. I also understand that there are several other R
> packages that relate to sequential clinical trials designs, such as
> AGSDest , GroupSeq, ldbounds, MChtest, PwrGSD, and Seqmon. Some of these
> seem fairly comprehensive while others seem to focus on a single approach.
> My questions center on the adequacy of SPLUS Seqtrial and the R Packages.
> I was wondering if there is anyone out there who would be familiar enough
> with these to comment on their relative merits. Will SPLUS Seqtrial or the
> R packages allow me to do all the designs Iâm ever likely to need? If I
> pay for SPLUS Seqtrial, will I get anything that I canât get using the
> various R packages? Are any of the R packages comprehensive? Or would it
> at least be possible to cover all the types of designs that are commonly
> used by employing a variety of R packages? What kind of validation work
> generally goes into an R package and how would this likely compare to the
> sort of validation work that has gone into Seqtrial?
> There may be other questions that I should be asking but havenât thought
> At any rate, if some of you would be willing to share some advice or
> insights Iâd greatly appreciate it.
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