[R] Script for dose proportionality assessment using power model and confidence interval criteria

[Jean-Louis Abitbol]

Dear R-Helpers

Has anyone written a script for the dose proportionality assessement
using the power model and the confidence interval criteria as described
in

- Gough at al. Assessment of dose proportionality: report from the
statisticians in the pharmaceutical industry in Drug Information
Journal,1995,     29:1039-1048 and/or
- Smith et al. Confidence interval criteria for assessment of dose
proportionality in Pharmaceutical Research, 2000, 20:1278-1283

As an aside, and before tweaking the source of function NCAanalyze in
the bear package, I wonder if anyone has a function for doing non
compartimental PK analysis by subject on a dataframe with subject, time
and concentration variates.  

Thanks in advance for sharing and helping me not re-invent the wheel
(which might be square given my R skills).

Best wishes, Jean-Louis

 
  
Jean-Louis Abitbol, MD
Chief Medical Officer
Trophos SA, Parc scientifique de Luminy, Case 931
Luminy Biotech Entreprises
13288 Marseille Cedex 9 France
Email: jlabitbol at trophos.com ---- Backup Email: abitbol at sent.com
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