[R] exact 95% confidence intervals

Frank E Harrell Jr f.harrell at vanderbilt.edu
Wed Sep 27 14:30:10 CEST 2006

Peter Dalgaard wrote:
> "XinMeng" <xmeng at capitalbio.com> writes:
>> Hello sir:
>> As to the 2*2 table format for reporting results comparing a new
>> test to true diagnosis,when I got the sensitivity and
>> specificity,how can I calculate the exact 95% confidence intervals
>> (based on the binomial distribution) for sensitivity and specificity
>> via R?
> Just run binom.test on the data from each column (or row, depending on
> which way you turn the tables).

But beware of exact binomial intervals - they are often not very 
accurate.  Wilson and other intervals are generally better.  For example 
see the binconf function in the Hmisc package.

Frank E Harrell Jr   Professor and Chair           School of Medicine
                      Department of Biostatistics   Vanderbilt University

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