[R] Nonlinear mixed effects model

[Spencer Graves]

      Have you read Pinheiro and Bates (2000) Mixed-Effects Models in S 
and S-Plus (Springer), especially the discussion of 'corStruct' classes 
in ch. 5 and the nonlinear mixed-effects models in Part II?  Bates has 
kept a small army of graduate students busy for over 20 years developing 
good ways to do things like this, and this book is probably the 
best-known product of that work. 

      Hope this helps. 
      Spencer Graves

Cam wrote:
> In nonlinear mixed effects models, SAS doesn't allow for free manipulation of
> the covariance matrix (you can only specify a "type", and our "type" doesn't
> exist). Can R accomplish this? For example:
>
> Parameters:
> B1= Beta 1i
> B2= Beta 2i
> G1= Gamma i
>
>
> y = B1 -(B1 - B2) exp { - G1 time} + e
>
> the covariance matrix for 
> (B1         [( covB1?     covB1B2   covB1G1
>  B2    ~      covB2B1    covB2?     covB2G1
>  G1)           covG1B1   covG1B2   covG1?   )]
>
> **If we want to specify covG1B1 and make everything else 0's, for example,
> what would the code look like? 
>
>
>
> Thanks for your time.
>