[R] FDR analyses: minimum number of features

Dupont, William william.dupont at Vanderbilt.Edu
Fri Sep 23 15:18:01 CEST 2005

 Thanks.  That is an excellent idea.  Bill

-----Original Message-----
From: Spencer Graves [mailto:spencer.graves at pdf.com] 
Sent: Thursday, September 22, 2005 9:01 PM
To: Dupont, William
Cc: Kjetil Brinchmann Halvorsen; r-help at stat.math.ethz.ch
Subject: Re: [R] FDR analyses: minimum number of features

	  Have you considered Monte Carlo?  From previous work, you
could estimate a distribution for the differences to be detected and use
that as input to a Monte Carlo, computing thereby a distribution for FDR
as a function of distribution of differences and the number of features.

 From this, you could estimate probabilities for obtaining results that
were bogus vs. marginal, barely useful vs. highly accurate and plot them
vs. alternative budgets, etc.

	  I hope this comment makes more sense than my earlier nonsense.

	  spencer graves

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