[R] Degradation model

Huntsinger, Reid reid_huntsinger at merck.com
Fri May 20 16:50:54 CEST 2005

There's an extension to the package nlme using odesolve to estimate
parameters of models defined by ODEs. It's called nlmeODE and has a home
page here: http://sourceforge.net/projects/nlmeode/ ; it's on CRAN

Reid Huntsinger

-----Original Message-----
From: r-help-bounces at stat.math.ethz.ch
[mailto:r-help-bounces at stat.math.ethz.ch] On Behalf Of Klaus Kaae Andersen
Sent: Friday, May 20, 2005 7:12 AM
To: r-help at stat.math.ethz.ch
Subject: [R] Degradation model

Dear list,

I have a degradation model:

dX/dt = * I(X2)*( k1*X(t) )/( X(t)+k2 ) 

where X(t) is concentration at time t, and k1 and k2 are parameters
that I want to estimate. I(X) is a known inhibitor function.

My questions is whether this is implemented or easily computed in any
R package. I have searched the archives but without luck.

Any help or comments on this would be appreciated,
Klaus Andersen

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