[R] A model for disease progression

[Christian Schulz]

Perhaps the package msm (Multi-state Markov models in continuous time ) is
interesting for you?

christian




----- Original Message -----
From: "Damon Wischik" <djw1005 at cam.ac.uk>
To: "R-Help" <R-help at stat.math.ethz.ch>
Sent: Saturday, July 26, 2003 8:14 PM
Subject: [R] A model for disease progression


>
> I would be grateful for advice about the following problem. It's not
> directly R-related, but I'm hoping that R will help me analyse the
> following data.
>
> I have a table which indicates the progression of a certain age-related
> disease.  At a certain point in time, a population was sampled; and I have
> measurements for the age of each individual, and their disease stage.
> (Disease stage is an ordered factor, none<A<B<C<D.)
>
> I hypothesize that the rate of disease-onset depends on age, but that
> (once the disease has started) its rate of progression depends on the
> current disease stage and not on age.
>
> I would like to plot the data in a sensible way, to let me see if this
> hypothesis is reasonable, and to let me explore possible functional forms
> for the two rates.
>
> I can see how to plot the rate of disease onset. I could, for example,
> plot for each age the fraction of people who have acquired the disease by
> that age. But I don't know how to visualize the rate of disease
> progression.
>
> All suggestions (especially pointers to relevant literature or R packages)
> gratefully received!
>
> Damon.
>
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