[R] logsitic prediction

Troels Ring tring at mail1.stofanet.dk
Sat Sep 23 14:03:48 CEST 2000

Dear friends.
I have a paper (details below) examining the risk of renal failure after an 
operation. A logistic regression was done, and the coefficients to two 
regressors (age and creatinine) plus intercept with standard errors are 
given. These coefficients must be dependent in estimation, and when no 
details are given, I thought how I could most informatively get an 
impression as to how these standard errors materialized in uncertainty in 
predicting the risk of renal failure for a fellow age such and such etc.
The approach below gives very broad ranges but I can't see it is obviously 
wrong ?

#simulations for Schepens: Risk assessment of acute renal failure after
#thoracoabdominal aortic aneurysm surgery, Annals of Surgery 1994;219:400-407
#Final logistic regression has u = -14.42+0.1723*age+0.005481*crea
#and prob = exp(u)/(1+exp(u))
#coefficients are given with se: 4.71, 0.0649 and 0.0029 respectively;n=84
sd <- c(4.71,0.0649,0.0029)*sqrt(84)
mean <- c(-14.42,0.1723,0.0055)
prob <- function(age,crea) {
u <- rnorm(1000,mean[1],sd[1]) +age* rnorm(1000,mean[2],sd[2])+crea* 
summary( exp(u)/(1+exp(u)))}

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