[Rd] NY Times article

Nicholas Lewin-Koh nikko at hailmail.net
Sun Jan 11 20:26:13 CET 2009


Hi Frank,
Thank you for the correction, I don't work in clinical, so good you keep
me honest.
Nicholas
On Sun, 11 Jan 2009 09:21:23 -0600, "Frank E Harrell Jr"
<f.harrell at vanderbilt.edu> said:
> Nicholas please note that FDA does not require type III sums of squares, 
> LOCF, and the use of any particular software.  It is just the fact that 
> FDA does not disallow type III tests and LOCF that prevents pharma from 
> abandoning these terrible methods.
> 
> Frank
> -- 
> Frank E Harrell Jr   Professor and Chair           School of Medicine
>                       Department of Biostatistics   Vanderbilt University



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