Dear All,

Could you please help me to design a contrast for Differential Analysis?

....
constrast.matrix <- makeContrasts (
--------,
levels=design)
...


I have 4 groups.

A - normal
B - cancer
C - normal + drug
D - cancer + drug

I would like to find genes modulated in D versus C. These genes should be
not affected or change significantly in B versus A


Any suggestion?

Many thanks,

Paolo

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