hi Hugo,

We are not planning at the moment to have results() generate multiple
contrasts, but I will keep it in mind.

best,

Mike


On Mon, Dec 23, 2013 at 5:10 AM, Hugo Varet <hugo.varet@pasteur.fr> wrote:

> Dear Michael Love and list members,
>
> I'm used to analyze RNA-seq data with your nice DESeq2 package (1.2.0) and
> I sometimes have to test complex null hypotheses using contrasts. For one
> of my project, I would like using multiple contrasts, i.e. testing for
> example (H0: beta1-beta2 = beta3-beta4 = 0) against (H1: beta1-beta2 != 0
> and/or beta3-beta4 != 0), where the beta's are the regression coefficients
> of the models. To do so, I would like using a numeric matrix for the
> contrast argument in results(), but it only accepts a numeric vector.
>
> Hence, I was wondering if you planned to extend DESeq2 to the use of
> multiple contrasts?
>
> Best regards,
>
> Hugo
>
> --
> Hugo Varet
> Plate-Forme Transcriptome et Epigénome
> Institut Pasteur
>
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